Results 271 to 280 of about 383,310 (333)

The Importance of Apparent pKa in the Development of Nanoparticles Encapsulating siRNA and mRNA

Trends in Pharmacological Sciences, 2021
Polymer and lipid nanoparticles have been extensively used as carriers to address the biological barriers encountered in siRNA and mRNA delivery. In this review, we summarize the critical role of nanoparticle’s charges and ionizability in complexing RNAs,
Pratikkumar Patel, Nurudeen Mohammed Ibrahim, Kun Cheng   +2 more
exaly   +2 more sources

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

Cell, 2020
SUMMARY The fidelity of intracellular signaling hinges on the organization of dynamic activity architectures. Spatial compartmentation was first proposed over 30 years ago to explain how diverse G-protein-coupled receptors achieve specificity despite ...
Jason Z Zhang, Tsan-Wen Lu, Lucas M Stolerman   +2 more
exaly   +2 more sources

Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells

Cancer Cell, 2020
Using unbiased kinase profiling, we identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, suppresses SCLC expansion in ...
Garry L Coles, James T Webber, Jaya Sangodkar   +2 more
exaly   +2 more sources

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Epik: pKa and Protonation State Prediction through Machine Learning.

Journal of Chemical Theory and Computation, 2023
Epik version 7 is a software program that uses machine learning for predicting the pKa values and protonation state distribution of complex, druglike molecules.
Ryne C. Johnston, Kun Yao, Zachary A. Kaplan, Monica Chelliah, K. Leswing, Sean Seekins, Shawn Watts, David Calkins, Jackson Chief Elk, Steven V Jerome, Matthew P. Repasky, J. Shelley   +11 more
semanticscholar   +1 more source

MolGpka: A Web Server for Small Molecule pKa Prediction Using a Graph-Convolutional Neural Network

Journal of Chemical Information and Modeling, 2021
pKa is an important property in the lead optimization process since the charge state of a molecule in physiologic pH plays a critical role in its biological activity, solubility, membrane permeability, metabolism, and toxicity.
Xiaolin Pan, Hao Wang, Cuiyu Li, J. H. Zhang, Changge Ji   +4 more
semanticscholar   +1 more source

Very fast prediction and rationalization of pKa values for protein–ligand complexes

Proteins: Structure, Function and Bioinformatics, 2008
David M Rogers, Jan H Jensen
exaly   +2 more sources

Dynamics of signaling by PKA

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005
The catalytic and regulatory subunits of cAMP-dependent protein kinase (PKA) are highly dynamic signaling proteins. In its dissociated state the catalytic subunit opens and closes as it moves through its catalytic cycle. In this subunit, the core that is shared by all members of the protein kinase family is flanked by N- and C-terminal segments.
Susan S, Taylor, Choel, Kim, Dominico, Vigil, Nina M, Haste, Jie, Yang, Jian, Wu, Ganesh S, Anand   +6 more
openaire   +2 more sources

pKa values in organic chemistry – Making maximum use of the available data

Tetrahedron Letters, 2018
Acids and bases are ubiquitous. Sometimes, it is essential to know the accurate strength (pKa values) of the acids/bases to work with, but sometimes just acidity/basicity order is enough.
A. Kütt, Sigrid Selberg, I. Kaljurand, Sofja Tshepelevitsh, A. Heering, Astrid Darnell, Karl Kaupmees, Mare Piirsalu, I. Leito   +8 more
semanticscholar   +1 more source

PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis

Physiological Reviews, 2005
Stimulus-secretion coupling is an essential process in secretory cells in which regulated exocytosis occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While an increase in intracellular Ca2+concentration ([Ca2+]i) is the principal signal, other intracellular signals also are important in regulated exocytosis. In particular, the
Susumu, Seino, Tadao, Shibasaki
openaire   +2 more sources

Mitochondrial cAMP-PKA signaling: What do we really know?

Biochimica et Biophysica Acta - Bioenergetics, 2018
Mitochondria are key organelles for cellular homeostasis. They generate the most part of ATP that is used by cells through oxidative phosphorylation. They also produce reactive oxygen species, neurotransmitters and other signaling molecules.
Yasmine Ould Amer, Etienne Hebert-Chatelain   +1 more
semanticscholar   +1 more source