Results 281 to 290 of about 383,310 (333)
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Standardization of prekallikrein activator (PKA): the 1st International Standard for PKA
British Journal of Haematology, 1985SummaryA international collaborative study was carried out to establish an international standard for prekallikrein activator (PKA). The candidate material, coded 82/530, was assayed against the Office of Biologics (FDA) PKA reference preparation No. 2 (OoB 2) and the 1st British Reference Preparation for PKA.
P J, Kerry, A D, Curtis, D P, Thomas
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Journal of Chemical & Engineering Data, 1976
Aryl amines are approximately six orders of magnitude less basic than aliphatic amines. This decrease in basicity is attributed to both resonance and inductive effects. Van der Krogt and Wepster (9, 7 1) have measured the basicities of quinuclidine (l), benzoquinuclidine (2), and dibenzoquinuclidine (3) (pKa's 10.58, 7.79, and 4.46, respectively, at ...
Dennis J. Kreil, Vernon R. Sandel
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Aryl amines are approximately six orders of magnitude less basic than aliphatic amines. This decrease in basicity is attributed to both resonance and inductive effects. Van der Krogt and Wepster (9, 7 1) have measured the basicities of quinuclidine (l), benzoquinuclidine (2), and dibenzoquinuclidine (3) (pKa's 10.58, 7.79, and 4.46, respectively, at ...
Dennis J. Kreil, Vernon R. Sandel
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2020
Arguably, this is even more important than the previous one. Remember that we use the pK a scale to quantify the stability of carbanions. If it isn’t stable (high pKa) then it won’t be easy to form.
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Arguably, this is even more important than the previous one. Remember that we use the pK a scale to quantify the stability of carbanions. If it isn’t stable (high pKa) then it won’t be easy to form.
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Standardization of prekallikrein activator (PKA): the 1st British Reference Preparation for PKA
British Journal of Haematology, 1982Summary. A collaborative study on prekallikrein activator (PKA) has been carried out involving four laboratories for the purpose of establishing a British reference preparation for PKA. Samples of two plasma protein fractions (PPF) were assayed against participants’own supplies of the Bureau of Biologics Reference Preparation No. 2 (BoB 2).
P J, Kerry +3 more
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PKA, Germ Cells, and Fertility
Physiology, 2007Temporal and spatial regulation of PKA activity are essential for vigorous sperm motility and for the resumption of meiosis in oocytes, two events required for successful fertilization. Genetic mutations in mice that affect PKA signaling in germ cells lead to infertility and illustrate the importance of this pathway in mammalian reproduction.
Kimberly A, Burton, G Stanley, McKnight
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Predicting the pKa of Small Molecules
Combinatorial Chemistry & High Throughput Screening, 2011The biopharmaceutical profile of a compound depends directly on the dissociation constants of its acidic and basic groups, commonly expressed as the negative decadic logarithm pKa of the acid dissociation constant (Ka). We survey the literature on computational methods to predict the pKa of small molecules.
Matthias, Rupp +2 more
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A priori calculations of pKa's for organic compounds in water. The pKa of ethane
Journal of the American Chemical Society, 1987The enduring fascination of organic chemists with acidities and basicities reflects the fundamental importance of these concepts in understanding organic reactivity. Developing scales of aqueous acidities for weak organic acids is challenging in view of the need for extrapolations from organic solvents to water, ion-pairing and aggregation effects for ...
William L. Jorgensen +2 more
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Database Mining for pKa Prediction
Current Drug Discovery Technologies, 2005The acid dissociation constant (pKa) is the key parameter to define the extent of ionization of a drug molecule and is used for ADME properties evaluation via the pH-dependent distribution coefficient, logD. We present a method for pKa prediction using a predefined reference database and structural fingerprints based on a multilevel neighborhoods ...
Thierry, Kogej, Sorel, Muresan
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Peptides for disruption of PKA anchoring
Biochemical Society Transactions, 2006Adaptor or scaffolding proteins are at the basis of multiprotein complexes that spatially and temporally co-ordinate the propagation and integration of a broad range of cellular events. One class of scaffolding proteins are AKAPs (A-kinase-anchoring proteins).
C, Hundsrucker +2 more
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