Results 101 to 110 of about 3,912 (211)
Aldosterone as a renal growth factor [PDF]
, 2010 Aldosterone regulates blood pressure through its effects on the cardiovascular system and kidney. Aldosterone can also contribute to the development of hypertension that leads to chronic pathologies such as nephropathy and renal fibrosis.
Dooley, Ruth +2 more
core +1 more source
A Rare Diagnosis of Caroli Syndrome in a Young Patient
Clinical Case Reports, Volume 13, Issue 6, June 2025.ABSTRACT Caroli syndrome is a rare but serious congenital disorder associated with portal hypertension and polycystic kidney disease. Early diagnosis via imaging, particularly MRCP, is crucial to prevent life‐threatening complications such as cholangitis and biliary cirrhosis.
Elaheh Karimzadeh‐Soureshjani +4 more
wiley +1 more source
Type IV choledochal cyst with polycystic kidney disease: a case report
BMC Gastroenterology, 2020 Background Choledochal cysts are divided into 5 types. Physicians believe that Caroli disease (which refers to type V biliary cysts) is a special type of biliary cyst caused by a mutation in the PKHD1 gene and is associated with autosomal recessive ...
Yuxin He, Zhuwen Yu, Weichang Chen
doaj +1 more source
Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1 [PDF]
, 2014 Autosomal recessive polycystic kidney disease (ARPKD) results from mutations in the human PKHD1 gene. Both this gene, and its mouse ortholog, Pkhd1, are primarily expressed in renal and biliary ductal structures.
Boddu, R +10 more
core +1 more source
Heart dysfunction in a rat model with autosomal recessive polycystic kidney disease
The Journal of Physiology, Volume 603, Issue 9, Page 2551-2567, 1 May 2025.Abstract figure legend Our results demonstrate a diastolic dysfunction in animals with severe kidney disease. Moreover, chronic kidney disease (CKD)‐induced heart fibrosis and hypertrophy are associated with a dysregulation of cardiokine signalling in autosomal recessive polycystic kidney disease (ARPKD) animals. Created using BioRender.com.
Nathalie Gayrard +11 more
wiley +1 more source
Biliary sepsis complication with congenital hepatic fibrosis: an unexpected outcome
BMC Infectious Diseases, 2023 Background CHF (Congenital hepatic fibrosis) is a rare hereditary disease characterized by periportal fibrosis and ductal plate malformation. Little is known about the clinical presentations and outcome in CHF patients with an extraordinary complication ...
Jiawei Sun +12 more
doaj +1 more source
Unwrapping the Ciliary Coat: High‐Resolution Structure and Function of the Ciliary Glycocalyx
Advanced Science, Volume 12, Issue 16, April 24, 2025.The ciliary membrane is decorated in glycosylated proteins that define the interaction of the cilium with its environment. The main component of the ciliary coat of the green alga Chlamydomonas reinhardtii, FMG1, is characterized by cryo‐electron microscopy, proteomics, and live cell microscopy with flow‐based adhesion assays.
Lara M. Hoepfner +8 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 8, Issue 4, Page 758-770, April 2025.It is increasingly recognized that young, chow‐fed inbred mice poorly model the complexity of human carcinogenesis in multiple respects. In humans, age and adiposity are the major risk factors for the majority of malignancies. Although the development of genetically engineered mouse models (GEMM) of cancer has recapitulated many aspects of human cancer,
Iqbal M. Lone +4 more
wiley +1 more source
piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells [PDF]
, 2014 Transposable elements (TEs) occupy a large fraction of metazoan genomes and pose a constant threat to genomic integrity. This threat is particularly critical in germ cells, as changes in the genome that are induced by TEs will be transmitted to the next ...
Aravin, Alexei A. +3 more
core
Cancer Science, Volume 116, Issue 4, Page 1068-1081, April 2025.This study analyzed targeted sequencing of 6530 patients with metastatic Chinese colorectal cancer (CRC), identifying 36 novel driver genes with subgroup‐specific implications, such as ERBB4 affecting only male CRC patient outcomes. Additionally, the study utilized network‐based stratification to categorize microsatellite stable (MSS) and unstable (MSI)
Jianjiong Li +11 more
wiley +1 more source