Results 231 to 240 of about 22,457 (246)

PKM2 Blood.pdf

2023
Key Points: 1. Platelet activation increases PKM2 dimer formation, which modulates platelet functions and arterial thrombosis. 2. PKM2 regulates PI3Kmediated Akt and GSK3 signaling.
Nayak, Manasa, Ghatge, Madankumar, Flora, Gagan D., Dhanesha, Nirav, Jain, Manish, Markan, Kathleen R., Potthoff, Matthew J., R. Lentz, Steven, Chauhan, Anil K.   +8 more
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Activators of PKM2 in Cancer Metabolism

Future Medicinal Chemistry, 2014
Pyruvate kinase converts phosphoenolpyruvate to pyruvate, catalyzing the rate-limiting step of glycolysis. The M1 isoenzyme of pyruvate kinase (PKM1) is found in adult tissues; whereas, PKM2 is a splicesome variant found in embryonic and cancer cells.
Steven L, Warner, Kent J, Carpenter, David J, Bearss   +2 more
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PKM2 contributes to cancer metabolism

Cancer Letters, 2015
Reprogramming of cell metabolism is essential for tumorigenesis, and is regulated by a complex network, in which PKM2 plays a critical role. PKM2 exists as an inactive monomer, less active dimer and active tetramer. While dimeric PKM2 diverts glucose metabolism towards anabolism through aerobic glycolysis, tetrameric PKM2 promotes the flux of glucose ...
Nicholas, Wong, Diane, Ojo, Judy, Yan, Damu, Tang   +3 more
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PKM2 Is Essential for Bladder Cancer Growth and Maintenance

Cancer Research, 2021
Abstract Pyruvate kinase M2 (PKM2) has been shown to promote tumorigenesis by facilitating the Warburg effect and enhancing the activities of oncoproteins. However, this paradigm has recently been challenged by studies in which the absence of PKM2 failed to inhibit and instead accelerated ...
Yong Xia, Xing Wang, Yan Liu, Ellen Shapiro, Herbert Lepor, Moon-Shong Tang, Tung-Tien Sun, Xue-Ru Wu   +7 more
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PKM2, a potential target for regulating cancer

Gene, 2018
Aberrated glucose metabolism is a key future of cancer cells. Unlike normal cells, tumor cells favor glycolysis even in the presence of sufficient oxygen. Pyruvate kinase (PK), a key glucose metabolic enzyme, converts phosphoenolpyruvate (PEP) to pyruvate by transferring the high-energy phosphate group to adenosine diphosphate (ADP) to produce ...
Yu-huan Li, Xiao-feng Li, Jia-tao Liu, Hua Wang, Lu-lu Fan, Jun Li, Guo-ping Sun   +6 more
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PKM2: A New Player in the β-Catenin Game

Future Oncology, 2012
β-catenin is a key player in the regulation of gene expression during morphogenesis and tumorigenesis. Although its transactivation often results from stimulation of the Wnt signaling pathway, Wnt-independent regulation of β-catenin has also been observed in cancer cells.
Frédéric, Canal, Christine, Perret
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The potential roles of PKM2 in cerebrovascular diseases

International Immunopharmacology
Pyruvate kinase M2 (PKM2), a key enzyme involved in glycolysis,plays an important role in regulating cell metabolism and growth under different physiological conditions. PKM2 has been intensively investigated in multiple cancer diseases. Recent years, many studies have found its pivotal role in cerebrovascular diseases (CeVDs), the disturbances in ...
Ling, Ma, Huatao, Li, Hu, Xu, Dianwei, Liu   +3 more
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The multifaceted regulation and functions of PKM2 in tumor progression

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014
Tumor cells undergo metabolic rewiring from oxidative phosphorylation towards aerobic glycolysis to maintain the increased anabolic requirements for cell proliferation. It is widely accepted that specific expression of the M2 type pyruvate kinase (PKM2) in tumor cells contributes to this aerobic glycolysis phenotype. To date, researchers have uncovered
Zongwei, Li, Peng, Yang, Zhuoyu, Li
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PKM2 Moonlights as a Protein Kinase

Science Signaling, 2012
Pyruvate kinase M2 phosphorylates the transcription factor STAT3.
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