Results 251 to 260 of about 18,059 (264)
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Nuclear translocation of PKM2 mediates keratinocyte metabolic reprogramming in psoriasis
Experimental Dermatology, 2023PKM2 mediates the Warburg effects and is crucial for tumorigenesis, but its role in hyperplastic skin disorders remains elusive. In this study, we investigated the function of PKM2 in psoriatic keratinocytes. We found that PKM2 expression and its nuclear
Luting Yang +7 more
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Nature Reviews Molecular Cell Biology, 2012
Pyruvate kinase isoform M2 (PKM2) is a glycolytic enzyme that mediates the conversion of phosphoenolpyruvate (PEP) to pyruvate. It has been suggested that PKM2 may have additional enzymatic activities and localizes to the nucleus to regulate transcription. Here, the authors show that PKM2 can act as a kinase in the nucleus. They found that nuclear PKM2
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Pyruvate kinase isoform M2 (PKM2) is a glycolytic enzyme that mediates the conversion of phosphoenolpyruvate (PEP) to pyruvate. It has been suggested that PKM2 may have additional enzymatic activities and localizes to the nucleus to regulate transcription. Here, the authors show that PKM2 can act as a kinase in the nucleus. They found that nuclear PKM2
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PKM2: A New Player in the β-Catenin Game
Future Oncology, 2012β-catenin is a key player in the regulation of gene expression during morphogenesis and tumorigenesis. Although its transactivation often results from stimulation of the Wnt signaling pathway, Wnt-independent regulation of β-catenin has also been observed in cancer cells.
Frédéric Canal, Christine Perret
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Changes in PKM2 Associate with Prostate Cancer Progression
Cancer Investigation, 2014Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas.
Jason De Melo +5 more
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PKM2 Moonlights as a Protein Kinase
Science Signaling, 2012Pyruvate kinase M2 phosphorylates the transcription factor STAT3.
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The multifaceted regulation and functions of PKM2 in tumor progression
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014Tumor cells undergo metabolic rewiring from oxidative phosphorylation towards aerobic glycolysis to maintain the increased anabolic requirements for cell proliferation. It is widely accepted that specific expression of the M2 type pyruvate kinase (PKM2) in tumor cells contributes to this aerobic glycolysis phenotype. To date, researchers have uncovered
Zongwei Li +3 more
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The potential roles of PKM2 in cerebrovascular diseases
International ImmunopharmacologyPyruvate kinase M2 (PKM2), a key enzyme involved in glycolysis,plays an important role in regulating cell metabolism and growth under different physiological conditions. PKM2 has been intensively investigated in multiple cancer diseases. Recent years, many studies have found its pivotal role in cerebrovascular diseases (CeVDs), the disturbances in ...
Ling, Ma +3 more
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Naunyn-Schmiedeberg's Archives of Pharmacology, 2023
Mohd Rihan, S. Sharma
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Mohd Rihan, S. Sharma
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PKM2-induced protection from hyperglycaemia
Nature Reviews Nephrology, 2022openaire +2 more sources
The role of PKM2 in cancer progression and its structural and biological basis.
Journal of physiology and biochemistryBingxin Wu +4 more
semanticscholar +1 more source