Results 61 to 70 of about 2,862,840 (303)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
There's a voice that I enshrine
, 1938 F majorAndanteUna voce poco fa qui nel cor (There's a voice that I enshrine in my heart ...
Rossini, Gioacchino, 1792-1868 +3 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 1893 E minorAndanteO Lola, fair as flow'rs in beauty (O Lola, bianca come fior)56369-
http://id.loc.gov/authorities/names/n79063307 +1 more
core
, 2023 The old Norse term eið occurs in many Scandinavian place names. It denotes a passage over land between two trafficable waters, i.e., an isthmus which could be utilised as a portage for boats, people and cargo.
Reiersen, Håkon +1 more
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
, 1874 A flat majorMiserere, d'un alma gia vicina (Miserere, for one who's soul is nearing)M.G.793For duet and six-part ...
http://id.loc.gov/authorities/names/n79038460 +1 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 1908 E flat majorAndantinoDost thou know that fair land (Connais-tu le pays)5-84-68993-5(From cover) Opera ...
Thomas, Ambroise, 1811-1896 +1 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source