Results 111 to 120 of about 2,559,715 (278)
Social policy and international interventions in South East Europe: conclusions [PDF]
, 2007 This book has brought together three fields of study; that concerned with the role of international actors and their influence on national polices; changes taking place to social policies in the context of globalisation, transnationalism and ...
Deacon, Bob +2 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Gephyra, 2011 This paper aims to determine the route taken by Nicholas of Holy Sion in his journeys of sacrifice which are recorded in his Vita and in so doing, presents some suggestions as to the locations of Tragalassos and its territory and of the ten places with ...
Mehmet Alkan
doaj
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Social Justice in the EU – Index Report 2017 Social Inclusion Monitor Europe. Bertelsmann Stiftung Social Inclusion Monitor Europe 2017 [PDF]
, 2017 1. Europe is recovering not only economically, but also in the domain of social justice After years of downward movement, an upward trend in the domain of social justice is evident in the broad majority of EU member states.
Christof Schiller, Christof Schiller +3 more
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
, 2001 On title page: "The Esmée Fairbairn Charitable Trust" The Constitution Unit is carrying out a study of Scottish Independence, funded by a grant from the Esm6e Fairbairn Charitable Trust: how Scotland might gain independence, and the consequences for Scotland and the rest of the UK if she did.
openaire +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Summary and general conclusions: Childbearing Trends and Policies in Europe [PDF]
European fertility early in the 21st century was at its lowest level since the Second World War. This study explores contemporary childbearing trends and policies in Europe, and gives detailed attention to the past two or three decades. We felt motivated
Jan M. Hoem +3 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source