Results 31 to 40 of about 1,726,080 (246)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Emission metrics for quantifying regional climate impacts of aviation [PDF]
, 2017 This study examines the impacts of emissions from aviation in six source regions on global and regional temperatures. We consider the NOx-induced impacts on ozone and methane, aerosols and contrail-cirrus formation and calculate the global and regional ...
B. Aamaas +7 more
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Journal of Anthropological Archaeology, 2015 Abstract This paper describes the significance and relevance of concepts presented by Lewis Binford in “The Archaeology of Place” (1982) in studying the process of human colonization in Patagonia. Models and observational techniques inspired by and presented in that seminal paper have been instrumental in the discussion of the mobility of the first ...
openaire +2 more sources
The Chanka: Archaeological Research in Andahuaylas (Apurimac), Peru [PDF]
, 2010 In AD 1438 a battle took place outside the city of Cuzco that changed the course of South American history. The Chanka, a powerful ethnic group from the Andahuaylas region, had begun an aggressive program of expansion.
Aráoz Silva, Miriam +2 more
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Distanced from Dirt: Transnational Vietnam in the U.S. South [PDF]
, 2016 Article in special issue of south on Dirt and ...
Cynthia Wu
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Biodistance Analysis of North and South American Populations [PDF]
, 2018 This project was awarded third place in "History of People and Art" at the 2018 Richard J. And Martha D. Denman Undergraduate Research ForumArchaeological evidence suggests that humans were already present in both North and South America by 12.5-11.5 ...
Stamer, Julianne
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