Results 51 to 60 of about 2,084,614 (325)
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
The dual origin of cultivation in coconut and its implications for breeding : [Abstract W494] [PDF]
, 2012 Coconut is cultivated throughout the tropical coasts and is integral part of the way of life of many human communities. There is no related wild species. Many coconut varieties were identified. Stature and mating system distinguish selfpollinating Dwarfs
Baudouin, Luc, Gunn, Bee F.
core
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel +3 more
wiley +1 more source
The development of ASEAN from historical approach [PDF]
, 2011 Since ASEAN was established in 8 August 1967, ASEAN organization was only joined by five countries.Now ASEAN has become a successful regional organization in bringing the attention of the other countries in rest of the world.
Ajis, Mohd Na'eim +4 more
core
THE CITIES OF THE AMERICAS IN MODERN TIMES: A CASE STUDY ON TOPONYMY [PDF]
, 2016 During the 19th and 20th centuries many Italian migrants set out for the Americas, where peoples from other European countries, such as Spain, Portugal, France, Germany, England, Ireland etc. had already established themselves.
Cosimo Palagiano
core +2 more sources
FEBS Open Bio, EarlyView.In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada +3 more
wiley +1 more source
À l’origine du Nord, le chemin de la Chine [PDF]
, 1996 À peine abordée par les Européens, l'Amérique, du moins celle du Nord, est perçue comme un obstacle qu'il faut franchir. La première grande illusion du Nord américain (le Canada) est de sous-estimer l'étendue continentale en cherchant le passage vers l ...
Morissonneau, Christian
core +1 more source