Results 351 to 360 of about 14,611,928 (419)
Clinical Pharmacology &Therapeutics, EarlyView.Oral small molecule inhibitors of tumor necrosis factor alpha (TNFα) are emerging as attractive therapeutic agents for the treatment of various autoimmune diseases. Balinatunfib (SAR441566), a novel oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, changes the configuration of the soluble TNFα (sTNFα) trimer and prevents its ...
Nassr Nassr +12 more
wiley +1 more source
Supplementing Single‐Arm Trials with External Control Arms—Evaluation of German Real‐World Data
Clinical Pharmacology &Therapeutics, EarlyView.As single‐arm trials (SATs) are increasingly used in pharmaceutical research, the validity of such study designs needs to be critically assessed. We characterize the feasibility of supplementing SATs with real‐world data (RWD)‐derived external control arms by determining the proportion of SATs on breast cancer and amyotrophic lateral sclerosis (ALS ...
Martin Russek +2 more
wiley +1 more source
Examining the Financial Impact of Biodiversity‐Related Reputational Disasters
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT This research investigates the reaction of financial markets to biodiversity‐related corporate events, utilising an EGARCH model to assess the implications on stock returns and volatility. Results reveal that markets significantly respond to these events, demonstrating heightened sensitivity and volatility that underscore the financial ...
Erdinc Akyildirim, Shaen Corbet
wiley +1 more source
Cytometry Part B: Clinical Cytometry, EarlyView.ABSTRACT Anticipating the evolution of septic patients with community‐acquired pneumonia (CAP) is challenging for front‐line physicians in the Emergency Department (ED). Prognosis depends mainly on early identification, antibiotics, organ support, but also immune status.
Thomas Lafon +4 more
wiley +1 more source
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The Wiley Encyclopedia of Health Psychology, 2020
It has been reported to affect quality-of-life assessments. [3] In certain settings placebo interventions can influence patient-reported outcomes, especially pain and nausea, although it is difficult to distinguish patient-reported effects of placebo ...
Fabrizio Benedetti +1 more
openaire +2 more sources
It has been reported to affect quality-of-life assessments. [3] In certain settings placebo interventions can influence patient-reported outcomes, especially pain and nausea, although it is difficult to distinguish patient-reported effects of placebo ...
Fabrizio Benedetti +1 more
openaire +2 more sources
Placebos and the Placebo Effect in Drug Trials
Handbook of Experimental Pharmacology, 2019In this review, we explored different ways of controlling the placebo effects in clinical trials and described various factors that may increase/decrease the placebo effect in randomized placebo-controlled trials. These factors can be subdivided into four groups, and while not all factors are effective in every study and under all clinical conditions ...
Sibylle Klosterhalfen, Paul Enck
openaire +4 more sources
Philosophy of Pain, 2018
Until the 1960s, physicians in the United States could legally prescribe “placebo” on a prescription pad and handed to a patient. It was not unethical to do so. Placebo had long been known to be an effective treatment for various medical conditions. For millennia, physicians new that many of their treatments were ineffective and that many conditions ...
Jennifer Corns
openaire +2 more sources
Until the 1960s, physicians in the United States could legally prescribe “placebo” on a prescription pad and handed to a patient. It was not unethical to do so. Placebo had long been known to be an effective treatment for various medical conditions. For millennia, physicians new that many of their treatments were ineffective and that many conditions ...
Jennifer Corns
openaire +2 more sources
Choice and the Placebo Effect: A Meta-analysis.
Annals of Behavioral Medicine, 2022BACKGROUND Choice has been proposed as a method of enhancing placebo effects. However, there have been no attempts to systematically evaluate the magnitude, reliability, and moderators of the influence of choice on the placebo effect.
Biya Tang +4 more
semanticscholar +1 more source
European Journal of Nuclear Medicine and Molecular Imaging, 1997
The placebo effect will have a growing importance in the field of nuclear medicine as the potentials for palliative therapy with internal sources are realized. It is important for nuclear medicine physicians and their colleagues to be familiar with the role of placebo responses in clinical trials, especially when such trials involve the subjective ...
Mary Jane Heeg +2 more
openaire +2 more sources
The placebo effect will have a growing importance in the field of nuclear medicine as the potentials for palliative therapy with internal sources are realized. It is important for nuclear medicine physicians and their colleagues to be familiar with the role of placebo responses in clinical trials, especially when such trials involve the subjective ...
Mary Jane Heeg +2 more
openaire +2 more sources
JBJS Reviews, 2018
Background: Guidelines recommending various nonoperative treatments for patients with knee osteoarthritis remain inconsistent. Much of this controversy relates to what constitutes a clinically important effect.
C. Vannabouathong +6 more
semanticscholar +1 more source
Background: Guidelines recommending various nonoperative treatments for patients with knee osteoarthritis remain inconsistent. Much of this controversy relates to what constitutes a clinically important effect.
C. Vannabouathong +6 more
semanticscholar +1 more source