Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness [PDF]
, 2018 BACKGROUND: There are conflicting data on the effects of antipsychotic medications on delirium in patients in the intensive care unit (ICU). METHODS: In a randomized, double-blind, placebo-controlled trial, we assigned patients with acute ...
Bernard, G.R. +31 more
core +1 more source
"AI enhances our performance, I have no doubt this one will do the same": The Placebo effect is robust to negative descriptions of AI [PDF]
arXiv, 2023 Heightened AI expectations facilitate performance in human-AI interactions through placebo effects. While lowering expectations to control for placebo effects is advisable, overly negative expectations could induce nocebo effects. In a letter discrimination task, we informed participants that an AI would either increase or decrease their performance by
arxiv
Randomised controlled trial of homoeopathy versus placebo in perennial allergic rhinitis with overview of four trial series [PDF]
, 2000 OBJECTIVE: To test the hypothesis that homoeopathy is a placebo by examining its effect in patients with allergic rhinitis and so contest the evidence from three previous trials in this series.
Aitchison, T, +4 more
core +2 more sources
Decomposing Triple-Differences Regression under Staggered Adoption [PDF]
arXiv, 2023 The triple-differences (TD) design is a popular identification strategy for causal effects in settings where researchers do not believe the parallel trends assumption of conventional difference-in-differences (DiD) is satisfied. TD designs augment the conventional 2x2 DiD with a "placebo" stratum -- observations that are nested in the same units and ...
arxiv
Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source
Should we reconsider the routine use of placebo controls in clinical research?
Trials, 2012 Background Modern clinical-research practice favors placebo controls over usual-care controls whenever a credible placebo exists. An unrecognized consequence of this preference is that clinicians are more limited in their ability to provide the benefits ...
Avins Andrew L +4 more
doaj +1 more source
Glucose and cognitive performance : the effects of glucose on memory and sustained attention : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University [PDF]
, 2004 The effects of glucose on tasks of declarative memory, and sustained attention were examined. These effects were also investigated with regard to the age of the participant.
Richardson, Kelly
core
Effect of vitamin K2 on postural sway in older people who fall:a randomized controlled trial [PDF]
, 2019 OBJECTIVES: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people ...
Berg KO +12 more
core +5 more sources
Changing EDSS progression in placebo cohorts in relapsing MS: A systematic review and meta-regression [PDF]
PLoS ONE, 10(9):e0137052, 2015, 2013 Background: Recent systematic reviews of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS) revealed a decrease in placebo annualized relapse rates (ARR) over the past two decades. Furthermore, regression to the mean effects were observed in ARR and MRI lesion counts.
arxiv +1 more source
Molecular Oncology, EarlyView.We assessed the associations between the gut microbiota and outcome in metastatic triple‐negative breast cancer patients treated with chemotherapy alone or chemotherapy in combination with immunotherapy. Our data indicate that high gut microbiota alpha diversity was associated with improved clinical outcome and with benefit from immunotherapy.
Andreas Ullern +8 more
wiley +1 more source