Results 111 to 120 of about 484,364 (380)

Explicit and Implicit Processes in Human Aversive Conditioning [PDF]

open access: yes, 2006
The ability to adapt to a changing environment is central to an organism’s success. The process of associating two stimuli (as in associative conditioning) requires very little in the way of neural machinery.
Carter, Ronald McKell
core   +1 more source

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

open access: yesAdvanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang   +15 more
wiley   +1 more source

Placebo design in WHO-registered trials of Chinese herbal medicine need improvements

open access: yesBMC Complementary and Alternative Medicine, 2019
Background Physical identical and pharmacological inert are the basic requirements for placebo design, which are essential in clinical trials to evaluate the efficacy of an intervention.
Xuan Zhang   +5 more
doaj   +1 more source

How does observational learning produce placebo effects? : a model integrating research findings [PDF]

open access: yes, 2018
There is a growing body of evidence proving that observational learning, in addition to classical conditioning and verbal suggestions, may induce both placebo analgesia and nocebo hyperalgesia.
Bajcar, Elżbieta, Bąbel, Przemysław
core   +2 more sources

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

open access: yesAdvanced Science, EarlyView.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang   +6 more
wiley   +1 more source

Analysis of the Choice of Control in Acupuncture Clinical Trials Involving Patients with Breast Cancer

open access: yesJournal of Acupuncture Research
Control group selection in clinical trials is challenging, especially in acupuncture studies. A PubMed literature review of control groups in breast cancer acupuncture studies was performed and identified 67 studies for analysis.
Molly Siegel   +5 more
doaj   +1 more source

Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions

open access: yesAdvanced Science, EarlyView.
Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu   +5 more
wiley   +1 more source

Evaluation of sixteen antimotion sickness drugs under controlled laboratory conditions [PDF]

open access: yes
Evaluation of antimotion sickness drugs under controlled laboratory ...
Graybiel, A., Wood, C. D.
core   +1 more source

An extra reason to roll the dice: balancing harm, benefit and autonomy in 'futile' cases [PDF]

open access: yes, 2009
Oncologists frequently have to break bad news to patients. Although they are not normally the ones who tell patients that they have cancer, they are the ones who have to tell patients that treatment is not working, and they are almost always the ones who
Shaw, D.M.
core   +1 more source

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