Results 111 to 120 of about 116,751 (358)

Using instrumental variables to disentangle treatment and placebo effects in blinded and unblinded randomized clinical trials influenced by unmeasured confounders [PDF]

arXiv, 2016
Clinical trials traditionally employ blinding as a design mechanism to reduce the influence of placebo effects. In practice, however, it can be difficult or impossible to blind study participants and unblinded trials are common in medical research. Here we show how instrumental variables can be used to quantify and disentangle treatment and placebo ...
arxiv  

Placebo design in WHO-registered trials of Chinese herbal medicine need improvements

BMC Complementary and Alternative Medicine, 2019
Background Physical identical and pharmacological inert are the basic requirements for placebo design, which are essential in clinical trials to evaluate the efficacy of an intervention.
Xuan Zhang, Ran Tian, Chen Zhao, Xudong Tang, Aiping Lu, Zhaoxiang Bian   +5 more
doaj   +1 more source

Autonomous Self‐Evolving Research on Biomedical Data: The DREAM Paradigm

Advanced Science, EarlyView.
DREAM is a fully autonomous, self‐evolving biomedical research system capable of independently formulating scientific questions, performing analyses, and making new discoveries without human intervention. Validated in biomedical studies, DREAM significantly outperforms human scientists in research efficiency, accelerating scientific discovery and ...
Luojia Deng, Yijie Wu, Yongyong Ren, Hui Lu   +3 more
wiley   +1 more source

Analysis of the Choice of Control in Acupuncture Clinical Trials Involving Patients with Breast Cancer

Journal of Acupuncture Research
Control group selection in clinical trials is challenging, especially in acupuncture studies. A PubMed literature review of control groups in breast cancer acupuncture studies was performed and identified 67 studies for analysis.
Molly Siegel, Sylvia Baedorf Kassis, Weidong Lu, Im Hee Shin, Ting Bao, Barbara E. Bierer   +5 more
doaj   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Using placebos in research involving terminal illnesses

, 2011
Placebos are medical interventions that falsely lead patients to believe that they are receiving treatment and that their condition is being changed, when truly no specific treatment is being administered.
Day, Mark, Hicks, Ryan
core  

General Practitioners Attitudes towards Open-Label Placebos in Australia [PDF]

, 2018
This item is only available electronically.Objective: Multiple studies have found between 18-70% of medical professionals prescribe placebos, with general practitioners’ (GPs) reportedly being the highest prescribers.
Matthews, Kaitlin
core  

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo, Sinuo Chen, Jialei Sun, Ruchen Xu, Zhuoran Qi, Jie Li, Lianer Zhou, Yuan Fang, Tianshu Liu, Jinglin Xia   +9 more
wiley   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Rush to Judgment: The STI-Treatment Trials and HIV in Sub-Saharan Africa

, 2015
Introduction: The extraordinarily high incidence of HIV in sub-Saharan Africa led to the search for cofactor infections that could explain the high rates of transmission in the region.
Akobeng, Anzala, Auvert, Boily, Cartwright, Celum, Celum, Cohen, Deaton, Downs, Eileen Stillwaggon, Estellat, Feldmeier, Fleming, Ghys, Ghys, Ghys, Glynn, Grabowski, Gray, Gray, Gregson, Grosskurth, Grosskurth, Habicht, Harms, Hayes, Hayes, Hayes, Hotez, Hugonnet, Kamali, Kaul, Kaul, Kinzig, Kjetland, Kjetland, Korenromp, Larry Sawers, Larson, Leutscher, Looker, Martin, Modjarrad, Ng, Orroth, Orroth, Orroth, Padian, Pickering, Poggensee, Poggensee, Quigley, R ttingen, Rotchford, Rothman, Rothman, Rothman, Sangani, Schwartz, Schwebke, Sewankambo, Sexton, Stillwaggon, Stillwaggon, Taha, Todd, Victora, Watson-Jones, Watson-Jones, Wawer, WHO, Department of Measurement and Health Information, Wijgert, Wijgert, Wolday, World Health Organization, Worrall   +76 more
core   +2 more sources