A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness
Advanced Science, EarlyView.Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger +17 more
wiley +1 more source
Preventing Preterm Birth with Progesterone in Women with a Short Cervical Length from a Low-Risk Population: A Multicenter Double-Blind Placebo-Controlled Randomized Trial [PDF]
, 2015 Amelie van der Ven +14 more
openalex +1 more source
Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways
Advanced Science, EarlyView.This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li +10 more
wiley +1 more source
Placebo: een ingewikkeld fenomeen
Neuropraxis, 2016 Er heerst veel verwarring over het woord ‘placebo’ in de wetenschappelijke wereld. Dit lijkt vooral veroorzaakt te worden door de uiteenlopende betekenissen die wetenschappers aan dit woord toekennen, bijvoorbeeld een klinische onderzoeker of een neurowetenschapper. Bij het testen van geneesmiddelen willen onderzoekers weten of de therapie beter is dan
Olivier, Jocelien, Olivier, Berend
openaire +2 more sources
Advanced Science, EarlyView.Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang +7 more
wiley +1 more source
Conflictos en ética de investigación con seres humanos
Cadernos de Saúde PúblicaDesde la Declaración de Helsinki 2000, se intensificó y amplió un conflictivo debate que ha cuestionado muchos aspectos de la ética de investigación con seres humanos. La polémica incluye el uso de placebos, la aplicación del concepto de equiponderación,
Miguel H. Kottow
doaj
Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex
Advanced Science, EarlyView.In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang +13 more
wiley +1 more source
CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target
Advanced Science, EarlyView.This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang +2 more
wiley +1 more source
Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: a randomised placebo-controlled trial in 24 patients [PDF]
, 2011 M. Tauber +11 more
openalex +1 more source
Efficacy of a wheat polar lipid complex in reducing hair loss and improving hair growth in healthy women: A randomized, double‐blind, placebo‐controlled clinical study [PDF]
, 2023 Stéphanie Dudonné +2 more
openalex +1 more source