Results 281 to 290 of about 553,015 (386)

Effect of Palmitoylethanolamide Compared to a Placebo on the Gut Microbiome and Biochemistry in an Overweight Adult Population: A Randomised, Placebo Controlled, Double-Blind Study [PDF]

Romeo Batacan, David Briskey, Yadav S. Bajagai, Chelsie Smith, D. Smith Stanley, Amanda Rao   +5 more
openalex   +1 more source

A scoping review of thresholds for responder and time‐to‐event analysis of patient‐reported outcomes in breast cancer trials

British Journal of Clinical Pharmacology, EarlyView.
Patient‐reported outcomes (PROs) are essential for assessing clinical benefit and tolerability from the patient's perspective. In oncology trials, PRO data analysis often involves responder and time‐to‐event analyses, which depend on predefined thresholds to determine clinically meaningful change.
Anna Margarete Maria Thurner, Daniela Krepper, Micha Johannes Pilz, Lisa Marie Storz, Maike Thumfart, Johannes Maria Giesinger   +5 more
wiley   +1 more source

A Meta-analysis of Randomized Placebo-controlled Trials on the Effects of Probiotics for Autism Spectrum Disorders. [PDF]

Clin Psychopharmacol Neurosci
Huang PW, Liang SC, Sun CK, Cheng YS, Hung KC.   +4 more
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

The Efficacy and Safety of Nemolizumab in Patients with Prurigo Nodularis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Dermatol Pract Concept
Titou H.
europepmc   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Prescriptions of Essentially Placebo Treatments Among General Practitioners in 21 Countries.

JAMA Netw Open
Wolters F, Peerdeman K, Gussekloo J, Adler L, Asenova R, Kánská PB, Collins C, Dumitra GG, Howick J, Peštic SK, Kurpas D, Lazic V, Lingner H, Mallen CD, Missiou A, Peremans L, Petrazzuoli F, Pilv-Toom L, Poortvliet RKE, Thulesius HO, Torzsa P, Tsopra R, Tkachenko V, Viegas R, Evers AWM, Streit S.   +25 more
europepmc   +1 more source

Open-Label-Placebos can reduce pain, but not indigestion during gluten challenge in chronic pain patients. [PDF]

Front Psychol
Paschke-Dahl L, Klinger R.
europepmc   +1 more source

[Book Review of] \u3cem\u3eImplications of History and Ethics to Medicine: Veterinary and Human\u3c/em\u3e, edited by Lawrence B. McCullough and James Polk Morris, III [PDF]

, 1979
Benjamin, Walter W.
core   +1 more source

Effect of aspirin on renal disease progression in patients with type 2 diabetes: A multicenter, double-blind, placebo-controlled, randomized trial. The renaL disEase progression by aspirin in diabetic pAtients (LEDA) trial. Rationale and study design

, 2017
Francesco Violi, Giovanni Targher, Annarita Vestri, Roberto Carnevale, Maurizio Averna, Alessio Farcomeni, Andrea Lenzi, Francesco Angelico, Francesco Cipollone, Daniele Pastori   +9 more
openalex   +2 more sources