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Effects of open-label placebos in clinical trials: a systematic review and meta-analysis

Scientific Reports, 2021
Open-label placebos (OLPs) are placebos without deception in the sense that patients know that they are receiving a placebo. The objective of our study is to systematically review and analyze the effect of OLPs in comparison to no treatment in clinical ...
Stefan Schmidt
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Placebos and the Placebo Effect in Drug Trials

Handbook of Experimental Pharmacology, 2019
In this review, we explored different ways of controlling the placebo effects in clinical trials and described various factors that may increase/decrease the placebo effect in randomized placebo-controlled trials. These factors can be subdivided into four groups, and while not all factors are effective in every study and under all clinical conditions ...
Sibylle Klosterhalfen, Paul Enck
openaire   +4 more sources

Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice

BMJ, The, 2020
Despite their ubiquitous presence, placebos and placebo effects retain an ambiguous and unsettling presence in biomedicine. Specifically focused on chronic pain, this review examines the effect of placebo treatment under three distinct frameworks: double
Ted J Kaptchuk, Christopher C Hemond, Franklin G Miller   +2 more
exaly   +2 more sources

Effects of placebos without deception compared with no treatment: A systematic review and meta‐analysis

Journal of Evidence-Based Medicine, 2017
James E G Charlesworth, Igho J Onakpoya, Nia Roberts   +2 more
exaly   +2 more sources

Culture, context, and ethics in the therapeutic use of hallucinogens: Psychedelics as active super-placebos?

Transcultural Psychiatry, 2022
Following decades of prohibition and widespread concern about their mind-altering properties, there is increasing public, scholarly, and clinical interest in the therapeutic potential of psychedelic substances. Serotonergic substances in particular (DMT,
David Dupuis, S. Veissière
semanticscholar   +1 more source

The challenges of control groups, placebos and blinding in clinical trials of dietary interventions

Proceedings of the Nutrition Society, 2017
Heidi M Staudacher, Peter M Irving, Kevin Whelan   +2 more
exaly   +3 more sources

Are open‐Label Placebos Ethical? Informed Consent and Ethical Equivocations

Bioethics, 2016
Charlotte R Blease, Luana Colloca
exaly   +2 more sources