Results 131 to 140 of about 167,631 (303)

Tetraspanin‐ESCRT sorting drives miR‐29b packaging into extracellular vesicles to reverse fibrosis in intrauterine adhesions

BMEMat, EarlyView.
MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen, Jianfeng Wu, Shunhan Zhang, Siqi Huang, Yingjun Xie, Hongda Chen, Yinghong Yang, Lan Xiao, Ding Wang, Keke Wu, Xiaofang Sun   +10 more
wiley   +1 more source

Placental crises: disruptive selection and maternal under‐investment as the foundations of mammalian placental evolution and dysfunction

Biological Reviews, EarlyView.
ABSTRACT Among the vertebrates, mammals are notable for the dominance of live birth and placental nutrition. The structural diversity of the mammalian placenta is remarkable, despite sharing a single common ancestor and conserved physiological functions.
Davis Laundon, Neil J. Gostling, Ian G. Reddin, Bram G. Sengers, Pascale Chavatte‐Palmer, Rohan M. Lewis   +5 more
wiley   +1 more source

Humans are not unique: difficult birth is common in placental mammals

Biological Reviews, EarlyView.
ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
wiley   +1 more source

Analysis of Risk Factors for Severe Postpartum Hemorrhage

Clinical and Experimental Obstetrics & Gynecology
Background: The purpose of this study is to outline the probable causes of severe postpartum hemorrhage (sPPH), summarize its risk factors, and present strategies for its prevention and treatment.
Yongxin Zhang, Jing Zhang, Kaihua Guo, Yanan Gao, Yu Zhu, Guohua Zhang   +5 more
doaj   +1 more source

Single‐Cell Profiling Reveals Distinct Immune Hallmarks in Untreated Primary Colorectal and Liver Metastasis Cancers

Chronic Diseases and Translational Medicine, EarlyView.
Features the major cell type compositions among colon and liver metastasis. (A) The study design for single‐cell data analysis. (B) The annotated major cell types. Each type was labeled with a special color. (C) Dot plot of canonical marker genes for major cell types. (D) Bar plot of the percentage for each cell type in individuals. (E) Bar plot of the
Zhixun Zhao, Haipeng Chen, Xu Guan, Zheng Jiang, Zheng Liu, Ming Yang, Hengchang Liu, Tianli Chen, Shuangmei Zou, Yibo Gao, Xishan Wang   +10 more
wiley   +1 more source

Mitochondrial quality control alterations and placenta-related disorders

Frontiers in Physiology
Mitochondria are ubiquitous in eukaryotic cells. Normal maintenance of function is the premise and basis for various physiological activities.
Yamei Wu, Yamei Wu, Meng Li, Meng Li, Hao Ying, Ying Gu, Ying Gu, Yunlong Zhu, Yunlong Zhu, Yanfang Gu, Yanfang Gu, Lu Huang, Lu Huang   +12 more
doaj   +1 more source

Neuroendocrine aspects of placenta and pregnancy

, 2012
Placenta plays a central role in the regulation of physiological mechanisms of pregnancy, and in particular is the organ of communication between mother and fetus.
Torricelli, M., De Bonis, M., Luisi, S., De Leo, V., Petraglia, F., Severi, F. M.   +5 more
core   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Paternal DDT exposure induces sex-specific programming of fetal growth, placenta development and offspring’s health phenotypes in a mouse model

Scientific Reports
Mounting evidence suggests that environmentally induced epigenetic inheritance occurs in mammals and that traits in the progeny can be shaped by parental environmental experiences. Epidemiological studies link parental exposure to environmental toxicants,
Elaine Chen, Raquel Santana da Cruz, Aallya Nascimento, Meghali Joshi, Duane Gischewski Pereira, Odalys Dominguez, Gabriela Fernandes, Megan Smith, Sara P. C. Paiva, Sonia de Assis   +9 more
doaj   +1 more source

Transthyretin and the human placenta

, 2013
Since its discovery, transthyretin (TTR) has been regarded as an important hepatically derived protein carrier of thyroid hormones and retinol in blood. However, in more recent years it has been shown that TTR has other important functions.
Richard, K., Landers, K. A., Mortimer, R. H.   +2 more
core   +1 more source