Results 41 to 50 of about 15,358 (309)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Sixth annual conference on alaskan placer mining [PDF]
, 1984 An abridged format of papers, presentations and addresses given during the 1984 conference held on March 28-29, 1984, compiled and edited by Daniel E. Walsh and M.
Walsh, D.E., Wray, Susan
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Determination of priority areas for development within Selyshchanskyi placer using ArcGIS software
Мінеральні ресурси УкраїниThe geological characteristics of the Selyshchanskyi placer, which is the part of the Irshansk group of placers of the Volyn titanium-bearing district, are given.
T. V. Okholina +2 more
doaj +1 more source
Open Geosciences, 2016 A total of 112 Au-nuggets, collected from alluvial placer deposits of the Ingarinda River from the Guli massif, located in northem Siberia, Russia, were investigated.
Dvorani Sami N.
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Characterisation of gold from Fiji [PDF]
, 1995 This is a study of the variation in chemistry and inclusion mineralogy of bedrock and placer gold from Fiji. It forms part of a large project, undertaking gold characterisation from a wide range of geological environments in Ecuador, Zimbabwe ...
Henney, P.J., Naden, Jon
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Searching for Strongly Interacting Massive Particles (SIMPs) [PDF]
, 1999 We consider laboratory experiments that can detect stable, neutral strongly interacting massive particles (SIMPs). We explore the SIMP annihilation cross section from its minimum value (restricted by cosmological bounds) to the barn range, and vary the ...
C. S. Li +21 more
core +4 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source