Results 41 to 50 of about 709,242 (285)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Gold Hill Placer

, 1940
GOLD HILL PLACER Basin District (Cataract). Minerals Yearbook 1940. Page 357. One of the small scale sluicing placer producers in district.
WPA
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Material characteristic of Vetvisty creek placer gold and prospects for atypical-source deposits in the middle course of the Selennyakh river (Momsky and Abyisky district, Yakutia)

Известия высших учебных заведений: Геология и разведка
Background. The lower-middle course of the Selennyakh River in the Momsky and Abyisky districts of the Republic of Sakha, Yakutia, is characterized by a wide distribution of alluvial gold placers. The absence of obvious potential primary sources of these
A. M. Prasolov, O. V. Vladimirtseva
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Contaminant Removal and Precious Metal Recovery by Lateral Channel Filtration in Mining-Impacted Alluvial Floodplains

Frontiers in Water, 2020
Water quality impacts from artisanal and small-scale alluvial (placer) gold mining operations occur in developing economies across several continents including Asia, Africa, and South America.
William P. Johnson, Eddy Pazmiño, Logan Frederick, Cesar Ron, Andrea Chica, Luis Tapia   +5 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Gold Coin Placer

, 1935
GOLD COIN PLACER Gould-Stemple District (Stemple). Lewis & Clark County. Minerals Yearbook 1935 Sta. App. Page 169. Principal producers of placer gold in district.
WPA
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Pathfinder signatures in placer gold derived from Au-bearing porphyries.

, 2014
Porphyry and epithermal mineralization of early Late Cretaceous Age (ca. 76-74Ma) at Casino, Revenue/Nucleus and Sonora Gulch areas in the central and eastern Dawson Range in west-central Yukon is spatially related to numerous placer gold mining areas ...
Chapman, RJ, Grimshaw, MR, Mortensen, JK, Wrighton, T, Allan, MA, Casseman, S   +5 more
core   +5 more sources