Results 91 to 100 of about 4,396,031 (348)

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Remote sensing of the Earth as a part of research of assessing the volume of technogenic raw and the environmental situation during the exploitation of placers

Georesursy
It is known that one of the main nowadays problems of subsoil use is the depletion of reserves. Every year many researchers pay attention on mining waste as a source of replenishment of the resource base.
V. S. Litvintsev, V. I. Usikov, Yu. A. Ozaryan, V. S. Alekseev   +3 more
doaj   +1 more source

Magnetometer and direct-current resistivity studies in Alaska [PDF]

, 1941
During the past year and a half, the territorial Department of Mines in Alaska has conducted a modest experimental program for the purpose of determining the extent to which magnetic and resistivity methods can be used in interior Alaska in connection ...
Joesting, Henry R.
core  

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Environmental Gradient Favours Functionally Diverse Macrobenthic Community in a Placer Rich Tropical Bay

The Scientific World Journal, 2013
The present paper examines the functional diversity-environment relation in a placer rich tropical bay. Understanding the environmental variables that determine the biodiversity pattern will help in the effective conservation plans of coastal habitat ...
S. K. Sivadas, B. S. Ingole, C. E. G. Fernandes   +2 more
doaj   +1 more source

Glacial Erosion Drives High Summer Mercury Exports from the Yukon River, Canada. [PDF]

Environ Sci Technol Lett, 2023
Staniszewska KJ, Reyes AV, Cooke CA.
europepmc   +1 more source

A mineral reconnaissance survey of the Abington-Biggar-Moffat-area, south-central Scotland [PDF]

, 1979
Panned heavy mineral concentrates, mostly obtained from stream sediments, were collected from 195 sites in the Abington-Biggar-Moffat area. The project area, which lies immediately east of the formerly important mining district of Wanlockhead ...
Dawson, J., Floyd, J.D., Phillip, P.R.
core  

Selective Lithium Recovery via Photothermal Evaporation and Hydration‐Controlled Adsorption

Advanced Science, EarlyView.
A bilayer Mo‐LDH@Sponge composite is developed to couple interfacial photothermal evaporation with hydration‐controlled lithium adsorption. Solar‐induced heating dynamically regulates Li+ hydration and transport, enabling selective lithium capture from saline water. This work provides mechanistic insight into photothermal–adsorption coupling for energy‐
Yanan Pan, Yue Zhang, Guoliang Liu, Weiquan Zhan, Wencai Zhang   +4 more
wiley   +1 more source