Results 61 to 70 of about 313,977 (292)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Geomorphometric analysis of Zimbabwe’ digital elevation model and issues of exogenic metallogeny

open access: yesИзвестия высших учебных заведений: Геология и разведка
Background. The raw material base of the Republic of Zimbabwe covers numerous endogenic deposits of chromium, nickel, copper, platinum, gold, diamonds, and other minerals. Exogenic deposits are of less occurrence.
P. A. Ignatov   +3 more
doaj   +1 more source

Assessing gold-bearing potential of the Kvarhush area (Western slope of the Urals, Perm krai) [PDF]

open access: yesМинералогия
The paper examines the morphology and composition of native gold from placers of the Kvarkush region (Perm krai). Using optical and electron microscopy, 149 native gold grains from three placers are studied.
M.D. Shamsutdinov, S.V. Petrov
doaj   +1 more source

PREREQUISITES FOR THE FORMATION OF GOLD SPREADS ON THE UKRAINIAN SHIELD AND ON ITS SOUTHERN FRAMING

open access: yesГеологія і корисні копалини Світового океану, 2023
The presence of numerous native gold deposits of the Ukrainian Crystalline Shield (UCS), as well as the spread of placer gold manifestations, determines the high probability of the formation of precious metal placers with industrial parameters here.
I.E. Lomakin   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

About micro- and nanoscale gold in the veil of gold-bearing territories (on the example of a mineralization site in the basin of the river Adamikha, Amur region)

open access: yesGeoresursy
The article identifies the problem of the need to take into account micro- (1 mm to 0.12 microns) and nanoscale (<0.12 microns) gold in placers and weathering crusts in order to increase the objectivity of their and eroded ore objects potential ...
I. V. Kuznetsova, A. I. Dementienko
doaj   +1 more source

Hydraulic borehole mining method possible application at Middle Larba alluvial gold field

open access: yesE3S Web of Conferences, 2018
Gold on placer deposits is mainly extracted in two ways: open and underground. But the open method of mining has a great negative impact on the environment, and the mine method is characterized by high labor intensity, capital and operating costs.
Rochev Vikror
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

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