Results 101 to 110 of about 159,078 (305)

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, EarlyView.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

Phylogenetic analysis of variants of the Puumala virus (Hantaviridae: Orthohantavirus) circulating in the Saratov region

Вопросы вирусологии
The objective is to determine the complete nucleotide sequence and conduct a phylogenetic analysis of genome variants of the Puumala virus isolated in the Saratov region. Materials and methods.
Yaroslav M. Krasnov, Ekaterina V. Naidenova, Natalia P. Guseva, Tatyana A. Polunina, Natalya A. Sharapova, Ekaterina A. Sosedova, Nina V. Kotova, Kirill S. Zakharov, Andrey V. Kazantsev, Irina V. Domanina, Vladimir N. Chekashov, Mikhail M. Shilov, Evgeniy N. Kondratiev, Natalya A. Osina, Vladimir V. Kutyrev   +14 more
doaj   +1 more source

Several Cytokine Profile Parameters in West Nile Fever Patients

Проблемы особо опасных инфекций, 2011
Presented are the results of cytokines' (IL-1, IL-2, IFN-γ, and TNF-α, IL-10) level detection in blood sera of West Nile fever patients in the territory of Volgograd Region during the summer outbreak in 2010. Marked is a significant increase in IL-1, IFN-
S. I. Zhukova, V. V. Alekseev, A. V. Lipnitsky, A. A. Zankovich, I. V. Avrorova, V. A. Antonov, V. P. Smelyansky, G. A. Tkachenko, E. V. Putintseva, O. V. Zinchenko   +9 more
doaj   +1 more source

A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague

mBio, 2018
Following the deadly anthrax attacks of 2001, the Centers for Disease Control and Prevention (CDC) determined that Bacillus anthracis and Yersinia pestis that cause anthrax and plague, respectively, are two Tier 1 select agents that pose the greatest ...
Pan Tao, Marthandan Mahalingam, Jingen Zhu, M. Moayeri, J. Sha, W. S. Lawrence, Stephen H. Leppla, A. Chopra, V. Rao   +8 more
semanticscholar   +1 more source

Pan2‐Pan3 Complex‐Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus

Advanced Science, EarlyView.
Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Ziwei Lv, Junting Feng, Shenxian Zhou, Zhiguang Qu, Jun Peng, Xiao‐Lin Chen, Deng Chen   +6 more
wiley   +1 more source

DIAGNOSTIC POTENTIAL OF THE ERYTHROCYTIC IMMUNOGLOBULIN DIAGNOSTICUM FOR INDICATION AND IDENTIFICATION OF THE CAUSATIVE AGENTS OF PARTICULARLY DANGEROUS (DEEP) MYCOSES

Проблемы особо опасных инфекций, 2017
Objective of the study was to assess analytical and diagnostic sensitivity and specificity of the “Reagent kit. Erythrocytic coccidioidomycosal and histoplasmosal immunoglobulin dry diagnosticum”, designed for identification of causative agents of ...
I. V. Novitskaya, E. V. Prokhvatilova, A. V. Toporkov, D. V. Viktorov, M. Ya. Kulakov, E. V. Savina, V. G. Pushkar’, L. I. Belitskaya, N. A. Osina, Zh. A. Kas’yan, I. V. Shul’gina, O. A. Lobovikova   +11 more
doaj   +1 more source

The rise of pneumonic plague in Madagascar: current plague outbreak breaks usual seasonal mould

Journal of Medical Microbiology, 2019
&NA; Madagascar has just emerged from the grip of an acute urban pneumonic plague outbreak, which began in August 2017, before the usual plague season of October‐April and outside the traditional plague foci in the northern and central highlands.
A. Rabaan, Shamsah H. Al-Ahmed, Shahab A Alsuliman, Fatimah A Aldrazi, W. Alfouzan, S. Haque   +5 more
semanticscholar   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Plague in Zimbabwe from 1974 to 2018: A review article

PLoS Neglected Tropical Diseases, 2019
Plague is a zoonotic disease caused by the bacterium Yersinia pestis and is transmitted through the bites of infected rodent fleas. Plague is well known for causing 3 major human pandemics that have killed millions of people since 541 A.D.
Amon Munyenyiwa, M. Zimba, T. Nhiwatiwa, M. Barson   +3 more
semanticscholar   +1 more source

Direct Recycling of Mixed‐Oxide Cathodes: Balancing Cost, Performance and Environmental Trade‐Offs

Advanced Science, EarlyView.
Direct regeneration routes for mixed‐oxide lithium‐ion battery cathodes are systematically compared using harmonized techno‐economic, electrochemical, and environmental metrics. Solid‐state, hydrothermal, molten salt, electrochemical, and chemical relithiation methods are benchmarked to identify performance, cost, and sustainability trade‐offs.
Evgenii Beletskii, Elizaveta Evshchik, Anna Shikhovtseva, Valery Kolmakov, Andrey Popov, Svetlana Eliseeva, Lyubov Shmygleva, Yurii K. Gun'ko, Valentin Romanovski   +8 more
wiley   +1 more source