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Yersinia pestis: the Natural History of Plague
Clinical Microbiology Reviews, 2020 The Gram-negative bacterium Yersinia pestis is responsible for deadly plague, a zoonotic disease established in stable foci in the Americas, Africa, and Eurasia. Its persistence in the environment relies on the subtle balance between Y.
Didier Raoult, Michel Drancourt
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Genes and Immunity, 2019 Plague is a vector-borne disease caused by Yersinia pestis. Transmitted by fleas from rodent reservoirs, Y. pestis emerged
Christian E Demeure +2 more
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Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague
Nature Communications, 2018 The origin of Yersinia pestis and the early stages of its evolution are fundamental subjects of investigation given its high virulence and mortality that resulted from past pandemics. Although the earliest evidence of Y.
Maria A Spyrou, Rezeda I Tukhbatova
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Yersinia pestis DNA from Skeletal Remains from the 6th Century AD Reveals Insights into Justinianic Plague [PDF]
PLoS Pathogens, 2013 Yersinia pestis, the etiologic agent of the disease plague, has been implicated in three historical pandemics. These include the third pandemic of the 19(th) and 20(th) centuries, during which plague was spread around the world, and the second pandemic ...
David M Wagner +2 more
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The Justinianic Plague: An inconsequential pandemic?
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The Justinianic Plague (circa 541 to 750 CE) has recently featured prominently in scholarly and popular discussions. Current consensus accepts that it resulted in the deaths of between a quarter and half of the population of the ...
Lee Mordechai +2 more
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FPR1 is the plague receptor on host immune cells
Nature, 2019 The causative agent of plague, Yersinia pestis, uses a type III secretion system to selectively destroy immune cells in humans, thus enabling Y. pestis to reproduce in the bloodstream and be transmitted to new hosts through fleabites.
Patrick Osei-Owusu +2 more
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Respiratory Care Clinics, 2004
In the United States, plague poses a threat to humans from the infected animals in the endemic areas of the Western states. Plague may also be used in the near future as an agent of warfare or terrorism. Although the presentation of bubonic plague may be less of a problem, the septicemic and pneumonic forms present challenges to early diagnosis and ...
Angeline A, Lazarus, Catherine F, Decker
+7 more sources
In the United States, plague poses a threat to humans from the infected animals in the endemic areas of the Western states. Plague may also be used in the near future as an agent of warfare or terrorism. Although the presentation of bubonic plague may be less of a problem, the septicemic and pneumonic forms present challenges to early diagnosis and ...
Angeline A, Lazarus, Catherine F, Decker
+7 more sources
Plague vaccine: recent progress and prospects
Npj Vaccines, 2019 Three great plague pandemics, resulting in nearly 200 million deaths in human history and usage as a biowarfare agent, have made Yersinia pestis as one of the most virulent human pathogens.
Wei Sun, Amit K Singh
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Genome sequence of Yersinia pestis, the causative agent of plague
Nature, 2001 The Gram-negative bacterium Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth centuries), the ...
Julian Parkhill +2 more
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Vaccine, 2009
Killed whole cell vaccines for plague were first produced as long ago as the late 1890s and modified versions of these are still used, with evidence that they are efficacious against bubonic plague. Renewed efforts with modern technology have yielded new candidate vaccines which are less reactogenic, can be produced in a conventional pharmaceutical ...
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Killed whole cell vaccines for plague were first produced as long ago as the late 1890s and modified versions of these are still used, with evidence that they are efficacious against bubonic plague. Renewed efforts with modern technology have yielded new candidate vaccines which are less reactogenic, can be produced in a conventional pharmaceutical ...
openaire +3 more sources