Results 91 to 100 of about 9,260,529 (325)

A Viral RNA Silencing Suppressor Modulates Reactive Oxygen Species Levels to Induce the Autophagic Degradation of Dicer‐Like and Argonaute‐Like Proteins

Advanced Science, EarlyView.
Understanding the virus‐host arms race has been a fascinating topic in virology; contributing significantly to the development of treatments and control strategies for viral diseases. CHV1 employs a sophisticated counter‐defense mechanism in its fungal host by utilizing a viral silencing suppressor to inhibit fungal FMN reductase; thereby modulating ...
Shiyu Zhai, Tianxing Pang, Shiyu Peng, Shenshen Zou, Zhiping Deng, Nobuhiro Suzuki, Zhensheng Kang, Ida Bagus Andika, Liying Sun   +8 more
wiley   +1 more source

The Potential of Cognitive‐Inspired Neural Network Modeling Framework for Computer Vision

Advanced Science, EarlyView.
In article number 202507730, Guorun Li, Lei Liu, Yuefeng Du, and co‐workers present a cognitive modeling framework (CMF) to bridge the ‘representation gap’ and ‘conceptual gap’ between cognitive theory and vision deep neural networks (VDNNs). The research findings provide new insights and solid theoretical support for VDNN modeling inspired by ...
Guorun Li, Lei Liu, Xiaoyu Li, Yuefeng Du, Zhenghe Song, Xiuheng Wu   +5 more
wiley   +1 more source

Rodents and other small mammal reservoirs in plague foci in northeastern Brazil

Journal of Infection in Developing Countries, 2017
Introduction: Plague is an acute, infectious zoonotic disease, primarily of wild rodents and their fleas, that affects humans and other mammals. In Brazil, several plague foci are located in the northeast region.
Erika de Cássia Vieira da Costa, Marise Sobreira, Nilma Cintra Leal, Alzira Maria Paiva de Almeida   +3 more
doaj   +1 more source

A Porcine Monoclonal Antibody Targeting a Conserved GP4 Epitope Protects against In Vivo Infection via the Induction of Broad‐Spectrum PRRSV Neutralization

Advanced Science, EarlyView.
This study developed mAb‐5F2, a monoclonal antibody targeting conserved GP4 residues (Q48/I50), which blocks the GP4‐CD163 interaction, resulting in a 78–85% reduction in viral entry. Porcineized 5F2‐pFc prevented mortality in infected piglets, reduced pulmonary viral loads, and minimized lesions. This broad‐spectrum antibody platform overcomes vaccine
Xu Chen, Jiakai Zhao, Pinpin Ji, Xiaoxuan Li, Hui Niu, Dian Jiao, Lu Zhang, Qianyi Zhu, Xinyu Liu, Julian A. Hiscox, James P. Stewart, Yani Sun, Qin Zhao   +12 more
wiley   +1 more source

D3.1 GRAPEVINE Plagues and Diseases Models v1

, 2023
The main objective of Activity 3 (Models specification and implementation) of GRAPEVINE project is to define several models for the identification of diseases and plagues, and the way to mitigate their effects. These models represent: a physical model about the behaviour and evolution of diseases / plagues, identification of the diseases / plagues in ...
Moshou, Dimitrios, Paraskevas, Charalampos, Pantazi, Xanthoula-Eirini, Kechagias, Konstantinos, Tamouridou, Afroditi-Alexandra, Pliatsidis, Konstantnos, Pantazi, Evdoxi-Glykeria, Balduque, Joaquín, Vourlioti, Paraskevi, Kotsopoulos, Stelios, Lacueva-Pérez, Francisco José   +10 more
openaire   +1 more source

MoMtg1 Acts as a Novel Transcriptional Repressor of MoSwi6 During Appressorium‐Mediated Penetration in the Rice Blast Fungus

Advanced Science, EarlyView.
Appressoria are specialized penetration structures for many plant pathogenic fungi, demanding precise cell cycle control. This study unveils MoMtg1 as a transcriptional repressor of MoSwi6, orchestrating MoCYC1 expression during turgor‐driven cell cycle progression to enable appressorium‐mediated penetration. Moreover, a small‐molecule inhibitor ZS1619
Xingyu Wang, Ting Zhang, Qi Li, Chang‐An Ji, Lin Huang, Mingzhi Zhang, Leiyun Yang, Xinyu Liu, Muxing Liu, Gang Li, Zhengguang Zhang, Haifeng Zhang   +11 more
wiley   +1 more source

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning, Jie Wang, Yihui Zhang, Hongrui Li, Zenan Jiang, Xinyu Su, Xiao Yang, Xiaoxuan Wu, Bing Wei, Jianmin Ying, Jian Yan, Wenbin Li   +11 more
wiley   +1 more source

Delayed diagnosis of fatal pneumonic canine plague: clinical and pathologic features in two naturally infected Colorado dogs

BMC Veterinary Research, 2020
Background Plague caused by Yersinia pestis is a highly infectious and potentially fatal zoonotic disease that can be spread by wild and domestic animals.
Paula A. Schaffer, Connor S. Hershkowitz, Kristy L. Dowers, Jennifer L. Golchanour, Lauren J. Harris, Tawfik A. Aboellial, Paul S. Morley, Stephanie A. Brault, Kristy L. Pabilonia, Gary L. Mason, Jennifer A. House, Joshua B. Daniels   +11 more
doaj   +1 more source

Thermosensory TRPV Heterotetramers Drive Seasonal Polyphenism: Molecular Basis of CcIav/CcNan‐PKCα‐AKH/AKHR Signaling in Pear Psyllid Morph Transition

Advanced Science, EarlyView.
At 2 5 °C, thermal activation initiates: i) CcIav/CcNan heterotetramer assembly → Ca2⁺ influx; ii) CcPKCα phosphorylation → AKH signaling potentiation; iii) CcAKH1 binding to membrane‐localized CcAKHR → energy mobilization (lipid catabolism/glycogenolysis) and vitellogenin transport via follicular patency; iv) Oocyte maturation → summer‐form nymph ...
Jianying Li, Zhixian Zhang, Yilin Wang, Yue Yang, Jiarui Wang, Xueyi Ruan, Songdou Zhang   +6 more
wiley   +1 more source

The epidemic of Justinian (AD 542): a prelude to the Middle Ages

Acta Theologica, 2005
The epidemic that struck Constantinople and the surrounding countries during the reign of Justinian in the middle of the 6th century, was the first documented pandemic in history.
Francois P. Retief, Louise Cilliers
doaj   +1 more source