Results 51 to 60 of about 49,963 (311)

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Patterns of Human Plague in Uganda, 2008–2016

Emerging Infectious Diseases, 2017
Plague is a highly virulent fleaborne zoonosis that occurs throughout many parts of the world; most suspected human cases are reported from resource-poor settings in sub-Saharan Africa.
Joseph D. Forrester, Titus Apangu, Kevin Griffith, Sarah Acayo, Brook Yockey, John Kaggwa, Kiersten J. Kugeler, Martin Schriefer, Christopher Sexton, C. Ben Beard, Gordian Candini, Janet Abaru, Bosco Candia, Jimmy Felix Okoth, Harriet Apio, Lawrence Nolex, Geoffrey Ezama, Robert Okello, Linda Atiku, Joseph Mpanga, Paul S. Mead   +20 more
doaj   +1 more source

Targeted Thrombolysis via CCR2‐Engineered Macrophage‐Mimicking Microbubbles Safely Ablates Venous, Arterial, and Microvascular Thrombosis

Advanced Science, EarlyView.
CCR2‐Enhanced Macrophage Membrane–Camouflaged Microbubbles for MCP‐1–Mediated Thrombus Targeting and Ultrasound‐Triggered Urokinase Release. ABSTRACT The clinical management of thrombosis, a primary cause of death worldwide, is hampered by the limitations of current thrombolytic agents, including short half‐life and high risk of off‐target bleeding ...
Buying Li, Changjin Lu, Shijie Gao, Dandan Chen, Xue Heng, Kibret Mequanint, Malcolm Xing, Gaoxing Luo, Haisheng Li   +8 more
wiley   +1 more source

Plagues upon the Earth: Disease and the Course of Human History, by Kyle Harper [PDF]

, 2022
Samuel Cohn
openalex   +1 more source

Sugar‐Armored Pesticides: Self‐Assembled System for Enhanced Foliar Adhesion and Sustained Delivery of Hydrophobic Antimicrobials Against Bacterial Diseases

Advanced Science, EarlyView.
This study develops a sugar‐armored, self‐assembled pesticide delivery system that enhances foliar adhesion, provides sustained release, effectively disrupts biofilms, and demonstrates superior bactericidal activity for improved disease control.
Jinghan Yang, Juan Liu, Xiaohui Wang, Peiyi Wang   +3 more
wiley   +1 more source

A non-stationary relationship between global climate phenomena and human plague incidence in Madagascar.

PLoS Neglected Tropical Diseases, 2014
BackgroundPlague, a zoonosis caused by Yersinia pestis, is found in Asia and the Americas, but predominantly in Africa, with the island of Madagascar reporting almost one third of human cases worldwide.
Katharina S Kreppel, Cyril Caminade, Sandra Telfer, Minoarison Rajerison, Lila Rahalison, Andy Morse, Matthew Baylis   +6 more
doaj   +1 more source

Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus

eLife, 2016
The 14th–18th century pandemic of Yersinia pestis caused devastating disease outbreaks in Europe for almost 400 years. The reasons for plague’s persistence and abrupt disappearance in Europe are poorly understood, but could have been due to either the ...
Kirsten I Bos, Alexander Herbig, Jason Sahl, Nicholas Waglechner, Mathieu Fourment, Stephen A Forrest, Jennifer Klunk, Verena J Schuenemann, Debi Poinar, Melanie Kuch, G Brian Golding, Olivier Dutour, Paul Keim, David M Wagner, Edward C Holmes, Johannes Krause, Hendrik N Poinar   +16 more
doaj   +1 more source

A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration

Advanced Science, EarlyView.
Fibrotic scarring persistently challenges urethral reconstruction. This study introduces a conformal, wearable ultrasound bioelectronic system that overcomes this by reprogramming fibroblast fate. The device activates a developmental Wnt–FGF10 axis, driving fibroblasts toward a regenerative FGF10+ phenotype that promotes angiogenesis and matrix ...
Mingming Yu, Xingxuan Zhang, Huan Zhang, Jun Wang, Fang Chen, Xiaojun Cai, Yichen Huang, Yuanyi Zheng   +7 more
wiley   +1 more source

An Overview of the Plague Situation and Its Vectors in Iran [PDF]

Journal of Mazandaran University of Medical Sciences
Plague is an important and serious zoonotic disease caused by the bacterium Yersinia pestis. This study is a narrative review. The required data for the research were gathered through a search in search engines such as Google Scholar and international ...
Seyed Hassan Nikookar, Golnesa Bagheri, Omid Dehghan, Farzaneh Sahraee, Mahmoud Fazeli Dinan, Seyed Farzad Motevalli Haghi, Nasibeh Hosseini-Vasoukolaei, Mohammad Reza Bagheri   +7 more
doaj  

Hotspots of genetic change in Yersinia pestis

Nature Communications
The relative contributions of mutation rate variation, selection, and recombination in shaping genomic variation in bacterial populations remain poorly understood. Here we analyze 3318 Yersinia pestis genomes, spanning nearly a century and including 2336
Yarong Wu, Youquan Xin, Xiaoyan Yang, Kai Song, Qingwen Zhang, Haihong Zhao, Cunxiang Li, Yong Jin, Yan Guo, Yafang Tan, Yajun Song, Huaiyu Tian, Zhizhen Qi, Ruifu Yang, Yujun Cui   +14 more
doaj   +1 more source