Results 91 to 100 of about 494,040 (274)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Continuous improvement on the rationality of prophylactic injectable PPIs usage by a clinical pharmacist-led guidance team at a Chinese tertiary teaching hospital

Journal of International Medical Research, 2020
Objective We aimed to evaluate the effects of a clinical pharmacist-led-guidance-team (CPGT) on improving rational prophylactic injectable proton pump inhibitor use (PIPU) and to explore the application of the Plan–Do–Check–Act (PDCA) method in promoting
Yun Hong, Ziqi Ye, Zhe Gao, Yuefeng Rao
doaj   +1 more source

Education in 'life cycle sustainability assessment': caring for all 3 P's in one [PDF]

, 2013
Starting from the observation that externalities, reflecting societal concerns, emerge from costs and benefits which are not reflected in the market price, the authors of the paper emphasize the importance in education of life cycle sustainability ...
Ciroth, Andreas, Mazijn, Bernard, Ugaya, Cassia, Valdivia, Sonia   +3 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Application of the Plan-Do-Check-Action Cycle in Reducing the Incidence of Forearm Hematoma in Patients After Transradial Artery Percutaneous Coronary Interventions

Journal of Multidisciplinary Healthcare
Yanqiu Fan, Xiaoyan Zhou Department of Cardiology, Jinhu County People’s Hospital, Huaian City, People’s Republic of ChinaCorrespondence: Xiaoyan Zhou, Department of Cardiology, Jinhu County People’s Hospital, Jiangsu Province, Huaian City, People’s ...
Fan Y, Zhou X
doaj  

What can’t be ignored in service quality evaluation: Application contexts, tools and factors

Revista Facultad de Ingeniería Universidad de Antioquia, 2014
This  paper  locates  a  Relevant  Literary  Space  (RLS)  about  service  quality  evaluation,  between  2006  and  2011,  in  order  to  characterise  the  following:  service  typologies,  evaluation  approaches,  measurement  models,  reliability ...
Jorge Iván Pérez, Leandro Muñoz Giraldo   +1 more
doaj   +1 more source

Standards and Testing Agency annual report and financial statements 2012-2013: (for the year ended 31 March 2013) [PDF]

, 2013
Enabling power: Education Act 1996, s. 537A (4) (5) (6). Issued: 29.05.2013. Made: 20.05.2013. Laid: 29.05.2013. Coming into force: 28.06.2013. Effect: S.I. 2009/1563 amended.
Todd, Ian
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Risk identification and intervention efficacy evaluation of hospital-acquired infections in neurosurgery department based on failure mode and effect analysis

Shanghai yufang yixue
ObjectiveTo establish a regional risk assessment system for hospital-acquired infections in neurosurgery department of general hospital, and to evaluate its prevention and control effectiveness.MethodsFailure mode and effect analysis (FMEA) was used to ...
YANG Puyu, QIU Ye, YANG Ya, WEI Zhimin, ZHAO Jingru, ZHU Weiping, SHEN Yifeng, WANG Yuanping   +7 more
doaj   +1 more source

State of Alaska Election Security Project Phase 2 Report [PDF]

, 2008
A laska’s election system is among the most secure in the country, and it has a number of safeguards other states are now adopting. But the technology Alaska uses to record and count votes could be improved— and the state’s huge size, limited road ...
Ayers, Mark, Hoffman, David B., Martin, Stephanie, Mock, Kenrick, Picard, LuAnn   +4 more
core