Results 211 to 220 of about 147,176 (269)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

In-depth 3D exploration of autosomal dominant polycystic kidney disease through light sheet fluorescence microscopy. [PDF]

Sci Rep
Delgado-Rodriguez P, Vitoria I, Ríos-Muñoz GR, Bardia L, Lamanna-Rama N, Nicolas-Saenz L, Sporring J, Soto-Montenegro ML, Aldabe R, Colombelli J, Muñoz-Barrutia A.   +10 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

El Plan Colombia como estrategia de formación de estado = Plan Colombia As A Strategy For State Formation

, 2010
openaire   +1 more source

Anatomical relationship between the terminal thoracic duct and brachial plexus: A cadaveric study. [PDF]

Brain Spine
de Oliveira AJM, Siqueira MG, Telles JPM.   +2 more
europepmc   +1 more source

Experience and Influence of Lifestyle Redesign^® Training in French-Canadian Occupational Therapists. [PDF]

Can J Occup Ther
Lévesque MH, Levasseur M.
europepmc   +1 more source

Effectiveness of a Train-the-Trainer Pedagogical Pilot Workshop in Improving Educators' Knowledge and Competency in Objective Structured Clinical Examination Implementation. [PDF]

Cureus
Ben Amor A, Farhat H, Aounallah A, Naija W, Bouaziz A, Charfeddine B, Chelbi S, Bouallègue O, Ben Dhiab M.   +8 more
europepmc   +1 more source

Synthesis of a Highly Fluorescent Quinoxalino[2,3-<i>b</i>]quinoxaline Polycyclic Derivative via Intramolecular Michael Addition to a Squaramide Ring. [PDF]

J Org Chem
Picci G, Milia J, Lippolis V, Ricci PC, Frontera A, Gomila RM, Ojah EO, De Silva Weerakonda Arachchige RD, Orton JB, Coles SJ, Busschaert N, Caltagirone C.   +11 more
europepmc   +1 more source