Results 191 to 200 of about 785,168 (303)

Establishment of a Novel Method for Dose Distribution Verification in Stereotactic Radiosurgery (SRS) Using General Semiconductor Array Detectors. [PDF]

Cureus
Hirano S, Ito T, Yanagi Y, Kosaka H, Matsumoto K, Matsuo Y, Monzen H.   +6 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Ginkgolic acid attenuates echinococcus granulosus infection-induced hepatic fibrosis by inhibiting Smad4 SUMOylation. [PDF]

PLoS Negl Trop Dis
Chen Q, Dong D, Yu X, Jiang X, Jiang H, Hou J, Wang L, Xu J, Wu X, Chen X.   +9 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Mechanistic Evaluation of Roxadustat for Pulmonary Fibrosis: Integrating Network Pharmacology, Transcriptomics, and Experimental Validation. [PDF]

Pharmaceuticals (Basel)
Zhang C, Huang X, Ye H, Tang H, Huang M, Jia S, Shao J, Wu J, Yao X.   +8 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Identification of an efficient immunohistochemical panel for precise differential diagnosis of sebaceous carcinoma of eyelid. [PDF]

Discov Oncol
Yu S, Lin Q, Ren W, Ji T.
europepmc   +1 more source

Nuclear Iraq: Plan set back? [PDF]

Nature, 1980
openaire   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Antiproliferative and Pro-Apoptotic Effects of <i>Tuber borchii</i> Extracts on Human Colorectal Cancer Cells via p53-Dependent Pathway Activation. [PDF]

Metabolites
Carinci E, Castelli S, Vitiello L, Pennesi A, Amicucci A, Zambonelli A, Ciriolo MR, Stocchi V, Baldelli S.   +8 more
europepmc   +1 more source