Results 201 to 210 of about 3,802,470 (275)

The Effect of Nanoparticle Shape, Orientation, and Heterogeneity on the Optical Birefringence of Polymer Nanocomposites. [PDF]

J Phys Chem C Nanomater Interfaces
Li C, Edamadaka S, Glor E, Vettelson MJ, S Watkins N, Faber-Rico J, Composto RJ, Ferrier RC, Fakhraai Z.   +8 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Thickness-confined metastable phase transitions drive large piezoelectricity in ultrathin BiFeO₃. [PDF]

Sci Adv
Chen SJ, Zhu M, Wang JH, Shi T, Liu J, Wang Y, Zhu Y, Ma XL, Chen Z, Tang Y.   +9 more
europepmc   +1 more source

NEW PERSPECTIVES ON REGIONAL DEVELOPMENT : INTRODUCTION [PDF]

Daoqin TONG, David PLANE, Jaewon LIM, Sandy DALL’ERBA   +3 more
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Concurrent validation of OpenCap for identifying ACL re-injury risk factors during a drop jump test in a healthy cohort. [PDF]

Sci Rep
Färber B, Horsak B, Paternoster FK.
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Spiral phyllotaxis in the moss Physcomitrium patens emerges from simple division rules of the apical cell. [PDF]

Curr Biol
Cammarata J, Strauss S, Lane B, Kelly-Bellow R, Mancini L, Vernoux T, Coudert Y, Roeder AHK, Smith RS.   +8 more
europepmc   +1 more source