Results 11 to 20 of about 167 (120)

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Resonance graphs of plane bipartite graphs as daisy cubes

, 2023
We characterize all plane bipartite graphs whose resonance graphs are daisy cubes and therefore generalize related results on resonance graphs of benzenoid graphs, catacondensed even ring systems, as well as 2-connected outerplane bipartite graphs ...
Che, Zhongyuan, Tratnik, Niko, Pleteršek, Petra Žigert, Brezovnik, Simon   +3 more
core  

In‐Memory Continuous‐Time SAT Solver Based on Bidirectional 11‐T SRAM Macro

Advanced Intelligent Systems, EarlyView.
This article reported a continuous‐time (CT) Boolean satisfiability (SAT) problem solver using bidirectional 11T‐SRAM macro. The proposed system operates asynchronously using capacitor‐based gradient integration and maximizes the parallelism for SAT solving by in‐memory computing (IMC).
Dongseok Kwon, Tinish Bhattacharya, George Higgins Hutchinson, Dmitri Strukov   +3 more
wiley   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Eco‐Innovation, Economic Complexity, and Sustainability: A Bibliometric and Systematic Literature Review

Business Strategy and the Environment, EarlyView.
ABSTRACT This study systematizes the literature on eco‐innovation and economic complexity, aiming to understand how the sophistication of productive structures shapes countries' capacity to develop environmentally responsible innovations, and how eco‐innovation may, in turn, influence productive sophistication.
Gregory Matheus Pereira de Moraes, Diogo Ferraz   +1 more
wiley   +1 more source

Conditional Randomization Tests for the Specification of Interference Structure

Journal of Applied Econometrics, EarlyView.
ABSTRACT This study proposes specification tests for interference structure in causal inference with spillovers. We focus on experimental settings in which the treatment assignment mechanism is known. To test whether a given exposure mapping adequately summarizes the true interference structure, we develop conditional randomization tests by utilizing ...
Tadao Hoshino, Takahide Yanagi
wiley   +1 more source

Signed Projective Cubes, a Homomorphism Point of View

Journal of Graph Theory, EarlyView.
ABSTRACT The (signed) projective cubes, as a special class of graphs closely related to the hypercubes, are on the crossroad of geometry, algebra, discrete mathematics and linear algebra. Defined as Cayley graphs on binary groups, they represent basic linear dependencies.
Meirun Chen, Reza Naserasr, Alessandra Sarti   +2 more
wiley   +1 more source

Fractional Balanced Chromatic Number and Arboricity of Planar (Signed) Graphs

Journal of Graph Theory, EarlyView.
ABSTRACT A balanced ( p , q ) $(p,q)$‐coloring of a signed graph ( G , σ ) $(G,\sigma )$ is an assignment of q $q$ colors to each vertex of G $G$ from a platter of p $p$ colors, such that each color class induces a balanced set (a set that does not induce a negative cycle).
Reza Naserasr, Lan Anh Pham, Cyril Pujol, Huan Zhou   +3 more
wiley   +1 more source

Compact Brownian surfaces II. Orientable surfaces

, 2023
Fix an arbitrary compact orientable surface with a boundary and consider a uniform bipartite random quadrangulation of this surface with n faces and boundary component lengths of order √ n or of lower order.
Miermont, Grégory, Bettinelli, Jérémie   +1 more
core   +1 more source