Results 61 to 70 of about 1,073,846 (316)
Geometric Curvatures of Plane Symmetry Black Hole
Advances in High Energy Physics, 2013 We study the properties and thermodynamic stability of the plane symmetry black hole from the viewpoint of geometry. We find that the Weinhold curvature gives the first-order phase transition at N=1, where N is a parameter of the plane symmetry black ...
Shao-Wen Wei +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
Incidence geometry and universality in the tropical plane
, 2018 We examine the incidence geometry of lines in the tropical plane. We prove tropical analogs of the Sylvester-Gallai and Motzkin-Rabin theorems in classical incidence geometry.
Brandt, Milo +3 more
core +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Numerical program for analysis of three-dimensional supersonic exhaust flow fields (CHAR 3D) [PDF]
, 1974 Choice of reference plane orientation depends on specific nozzle geometry, with different configurations requiring different reference plane systems. In addition, for given configuration several reference systems may be used in different regions of flow ...
Dash, S. +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini +13 more
wiley +1 more source
IEEE Access, 2020 This article proposes a low-cost, high-gain, and vertically polarized deployable antenna utilizing kirigami pop-up geometry. It primarily utilizes a foldable polyethylene terephthalate sheet to produce kirigami geometry in association with a rectangular ...
Syed Imran Hussain Shah +2 more
doaj +1 more source
Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu +16 more
wiley +1 more source