Results 101 to 110 of about 86,037 (264)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

WORM Colorings of Planar Graphs

Discussiones Mathematicae Graph Theory, 2017
Given three planar graphs F,H, and G, an (F,H)-WORM coloring of G is a vertex coloring such that no subgraph isomorphic to F is rainbow and no subgraph isomorphic to H is monochromatic. If G has at least one (F,H)-WORM coloring, then W−F,H(G) denotes the
Czap J., Jendrol’ S., Valiska J.
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Facial [r,s,t]-Colorings of Plane Graphs

Discussiones Mathematicae Graph Theory, 2019
Let G be a plane graph. Two edges are facially adjacent in G if they are consecutive edges on the boundary walk of a face of G. Given nonnegative integers r, s, and t, a facial [r, s, t]-coloring of a plane graph G = (V,E) is a mapping f : V ∪ E → {1, . .
Czap Július, Šugerek Peter, Jendrol’ Stanislav, Valiska Juraj   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

An Extension of Kotzig’s Theorem

Discussiones Mathematicae Graph Theory, 2016
In 1955, Kotzig proved that every 3-connected planar graph has an edge with the degree sum of its end vertices at most 13, which is tight. An edge uv is of type (i, j) if d(u) ≤ i and d(v) ≤ j.
Aksenov Valerii A., Borodin Oleg V., Ivanova Anna O.   +2 more
doaj   +1 more source

Rainbowness of cubic plane graphs

Discrete Mathematics, 2006
Given a plane graph \(G\), the rainbowness \(\mathrm{rb}(G)\) of \(G\) is the smallest integer \(k\) such that any (not necessarily proper) coloring of the vertices of \(G\) with \(k\) colors involves a face all vertices of which receive distinct colors.
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Drawing Graphs in the Hyperbolic Plane [PDF]

, 1999
It is shown how one can draw graphs on surfaces of negative Euler characteristic by using hyperbolic geometry and hyperbolic circle packing representations. The same approach applies to drawings of hyperbolic tessellations.
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source