Results 151 to 160 of about 2,666,039 (345)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Fullerene graphs of small diameter
, 2016 A fullerene graph is a cubic bridgeless plane graph with only pentagonal and hexagonal faces. We exhibit an infinite family of fullerene graphs of diameter $\sqrt{4n/3}$, where $n$ is the number of vertices. This disproves a conjecture of Andova and \v{S}
Nicodemos, Diego, Stehlík, Matěj
core
Grid Drawings of 4-Connected Plane Graphs [PDF]
, 2001 Kenichiro Miura +2 more
openalex +1 more source
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, EarlyView.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
Models of Klein Surface Obstruction Graphs
Кібернетика та комп'ютерні технологіїThe task of researching the structure of graphs of given connectivity, which are obstructions for a given surface of non-oriented kind, and building their models, from which obstruction graphs are formed by removing or compressing a set of edges, is ...
Volodymyr Petrenjuk, Dmytro Petreniuk
doaj +1 more source
The Connectivities of Leaf Graphs of Sets of Points in the Plane [PDF]
, 2001 Atsushi Kaneko, Kiyoshi Yoshimoto
openalex +1 more source
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
FEBS Open Bio, EarlyView.The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr +5 more
wiley +1 more source
A new 4-chromatic edge critical Koester graph [PDF]
Discrete Mathematics Letters, 2023 Andrey A. Dobrynin
doaj +1 more source
ZETA FUNCTION AND VALUE SEMIGROUP OF COMPLEX PLANE CURVE SINGULARITIES
Tạp chí Khoa học Đại học Đà LạtIn the work by A’Campo and Oka (1996), Tschirnhausen resolution towers arose as a nice tool when studying complex irreducible plane curve singularities.
Tuan Hiep Dang +2 more
doaj +1 more source