Results 71 to 80 of about 391,866 (285)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Models of Klein Surface Obstruction Graphs
Кібернетика та комп'ютерні технологіїThe task of researching the structure of graphs of given connectivity, which are obstructions for a given surface of non-oriented kind, and building their models, from which obstruction graphs are formed by removing or compressing a set of edges, is ...
Volodymyr Petrenjuk, Dmytro Petreniuk
doaj +1 more source
Some Operations on Complex Fuzzy Graphs
Ratio Mathematica, 2023 In this paper we discussed about some types of complex fuzzy graphs which is the extension of fuzzy graph. As the membership value of elements of fuzzy graph is in between 0 and 1.
Azhagendran N, Mohamed Ismayil A
doaj +1 more source
Implementing path coloring algorithms on planar graphs [PDF]
, 2017 Master's Project (M.S.) University of Alaska Fairbanks, 2017A path coloring of a graph partitions its vertex set into color classes such that each class induces a disjoint union of paths.
Bross, Daniel Aven
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Mixing Times of Markov Chains on Degree Constrained Orientations of Planar Graphs [PDF]
Discrete Mathematics & Theoretical Computer Science, 2017 We study Markov chains for $\alpha$-orientations of plane graphs, these are orientations where the outdegree of each vertex is prescribed by the value of a given function $\alpha$.
Stefan Felsner, Daniel Heldt
doaj +1 more source
The complexity of approximating the matching polynomial in the complex plane
, 2021 We study the problem of approximating the value of the matching polynomial on graphs with edge parameter $\gamma$, where $\gamma$ takes arbitrary values in the complex plane.
Bezakova, Ivona +3 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Cyclic Permutations in Determining Crossing Numbers
Discussiones Mathematicae Graph Theory, 2022 The crossing number of a graph G is the minimum number of edge crossings over all drawings of G in the plane. Recently, the crossing numbers of join products of two graphs have been studied.
Klešč Marián, Staš Michal
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source