Results 171 to 180 of about 3,522,268 (236)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Uniaxial Stress Enhanced Anisotropic Magnetoresistance and Superconductivity in the Kagome Superconductor LaRu₃Si₂. [PDF]

Adv Mater
Kral P, Sazgari V, Ge Y, Gerguri O, Spitaler M, Graham JN, Nakamura H, Bartkowiak M, Nakatsuji S, Luetkens H, Simutis G, Xu G, Guguchia Z.   +12 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Bio-Inspired Gradient Coatings Enhance the Leading Edge Erosion Resistance of Wind Blades. [PDF]

Adv Sci (Weinh)
Guevara-Sotelo NS, Teuwen J, Masania K.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Ultrahigh flow strength in shocked nanopolycrystalline diamond. [PDF]

Sci Adv
Hari A, Katagiri K, Li W, Luccioni DP, Lin R, Parsons SE, Xu Z, Hari R, Reddy T, Cubit EW, Amouretti A, Eggert JH, Inubushi Y, Irifune T, Irvine SJ, Kodama R, Koenig M, Madril L, Matsuoka T, Miyanishi K, Nakamura H, Nishiyama N, Okuchi T, Ota M, Sekine T, Seto Y, Shinmei T, Sueda K, Tange Y, Takagi S, Togashi T, Umeda Y, Wang Y, Yabashi M, Yabuuchi T, Ozaki N, Dresselhaus-Marais LE.   +36 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Buckling Analysis of Thin-Walled Laminated Plates Considering In-Plane and Out-of-Plane Coupling Effects Under Complex In-Plane Loads. [PDF]

Materials (Basel)
Kolakowski Z, Teter A.
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Impact of Surface Effects on Support-Loss Mechanisms in Micro-/Nano-Beam Resonators. [PDF]

Nanomaterials (Basel)
Chen Y, Jian X, Yang S, Yao G, Jiao W, Chen S.   +5 more
europepmc   +1 more source