Results 101 to 110 of about 2,323,816 (303)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Networks of gravitational wave detectors and three figures of merit
, 2011 This paper develops a general framework for studying the effectiveness of networks of interferometric gravitational wave detectors and then uses it to show that enlarging the existing LIGO-VIRGO network with one or more planned or proposed detectors in ...
Abadie J +22 more
core +4 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
PROBABILISTIC ASSESSMENT OF NECESSITY IN REPAIR AND ITS TYPE FOR BUILDING AND ITS ELEMENTS
Наука и техника, 2017 The existing normative documents consider 100%-wear as an extreme limit for operation of constructional element or structure. While using probabilistic rate of physical wear and determining the necessity in repair 100%-wear is assumed on the basis of ...
S. N. Osipov, D. A. Pozdniakov
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Application of Labour Growth Theory to the Analysis of Soviet Stagnation
AlterEconomicsThe causes of stagnation and crisis in the Soviet economic system remain a topic of ongoing debate. Mainstream economists often attribute its downfall to fundamental flaws in its economic model.
Aleksey A. ZOLOTUKHIN
doaj +1 more source
Flexibility in Investments: Exploratory Survey on How Finnish Companies Deal with Flexibility in Capital Budgeting [PDF]
Flexibility is an important issue when investments are being planned and valued. How flexibility inherent in investments is utilised and exploited is, therefore, of great importance to the accuracy of the plans and the valuation.
Collan, Mikael, Långström, Stefan
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Low Background Signal Readout Electronics for the MAJORANA DEMONSTRATOR
, 2015 The MAJORANA DEMONSTRATOR is a planned 40 kg array of Germanium detectors intended to demonstrate the feasibility of constructing a tonne-scale experiment that will seek neutrinoless double beta decay ($0\nu\beta\beta$) in $^{76}\mathrm{Ge}$.
Abgrall, N. +67 more
core +2 more sources