Results 51 to 60 of about 5,191,174 (218)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Modulation of plant immunity by atmospheric CO2 [PDF]

, 2016
The continuously increasing CO2 levels in the atmosphere is considered to be core among climate changes and is expected to affect plant diseases in the future, posing a new challenge for future strategies in plant protection.
Sub Plant-Microbe Interactions, Zhou, Y., Plant Microbe Interactions   +2 more
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Molecular aspects of plant disease susceptibility: Arabidopsis genes affecting downy mildew infection [PDF]

, 2013
Interactions of plants with pathogenic microorganisms are influenced by multiple biotic and abiotic factors. The host immune system can detect pathogens and restrict their growth and development, but also non-immunity related host factors and processes ...
Lapin, D., Sub Plant-Microbe Interactions, Plant Microbe Interactions   +2 more
core   +1 more source

Fungal Endopolygalacturonases Are Recognized as Microbe-Associated Molecular Patterns by the Arabidopsis Receptor-Like Protein RESPONSIVENESS TO BOTRYTIS POLYGALACTURONASES1 [PDF]

, 2014
Plants perceive microbial invaders using pattern recognition receptors that recognize microbe-associated molecular patterns. In this study, we identified RESPONSIVENESS TO BOTRYTIS POLYGALACTURONASES1 (RBPG1), an Arabidopsis (Arabidopsis thaliana ...
Elberse, J., Essenstam, B., Tjoitang, D., Plant Microbe Interactions, Liebrand, T.W.H., Elberse, Joyce, van den Ackerveken, Guido, van Kan, J.A.L., van den Ackerveken, G., Tagkalaki, P., Kars, I., Sub Plant-Microbe Interactions, Zhang, L., Wagemakers, L.   +13 more
core   +1 more source

MetaFlowTrain: a highly parallelized and modular fluidic system for studying exometabolite-mediated inter-organismal interactions

Nature Communications
Metabolic fluxes between cells, organisms, or communities drive ecosystem assembly and functioning and explain higher-level biological organization. Exometabolite-mediated inter-organismal interactions, however, remain poorly described due to technical ...
Guillaume Chesneau, Johannes Herpell, Sarah Marie Wolf, Silvina Perin, Stéphane Hacquard   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Hormonal signaling in plant immunity [PDF]

, 2016
Insect hervivores and pathogens are a major problem in agriculture and therefore, control of these pests and diseases is essential. For this, understanding the plant immune response can be instrumental. The plant hormones salicylic acid (SA) and jasmonic
Sub Plant-Microbe Interactions, Plant Microbe Interactions, Caarls, L.   +2 more
core  

Shoot- and root-borne cytokinin influences arbuscular mycorrhizal symbiosis [PDF]

, 2016
The arbuscular mycorrhizal (AM) symbiosis is functionally important for the nutrition and growth of most terrestrial plants. Nearly all phytohormones are employed by plants to regulate the symbiosis with AM fungi, but the regulatory role of cytokinin (CK)
Sub Plant-Microbe Interactions, Rebeca Cosme, M.P., Plant Microbe Interactions   +2 more
core   +1 more source