Results 111 to 120 of about 25,012,692 (251)

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Additional file 1 of Plasma lipids and glycaemic indices in Australians following plant-based diets versus a meat-eating diet

Supplementary Material ...
Austin, Grace, Ferguson, Jessica J. A., Eslick, Shaun, Oldmeadow, Christopher, Wood, Lisa G., Garg, Manohar L.   +5 more
openaire   +1 more source

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source

Reduction of Low-Density Lipoprotein Cholesterol through Plant-Based Diets: A Scoping Review [PDF]

openBackground: Cardiovascular disease (CVD) is the leading cause of death in the world. High levels of low-density lipoprotein cholesterol (LDL-C) are recognized as a key modifiable factor of CVD and currently managed by pharmacological therapies such ...
KIM, MONIKA
core  

Plant-based dietary patterns and incident diabetes in the Atherosclerosis Risk in Communities (ARIC) Study

Objective: Plant-based dietary patterns emphasize plant foods and minimize animal-derived foods. We investigated the association between plant-based dietary patterns and diabetes in a community-based U.S. sample of Black and White adults. Research Design
Valerie K Sullivan (13357530), Hyunju Kim (17387413), Casey M. Rebholz (8626101), Laura E. Caulfield (416330), Lyn M Steffen (4683679), Elizabeth Selvin (17048860)   +5 more
core   +1 more source

Plant-based diet dan sindrom metabolik: uji pendahuluan pada komunitas plant-based diet Bandung [PDF]

Association between plant-based diet and metabolic syndrome: a pilot study on Bandung plant-based diet communityBackground: Metabolic syndrome is a cluster of disorders related to cardiometabolic abnormalities that are experienced by two out of five ...
Fitria, Nita, Purba, Ambrosius, Faiza, Tiara, Luftimas, Dimas Erlangga, Fatimah, Siti Nur, Lubis, Leonardo   +5 more
core   +4 more sources

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Guilt by association: Plant-based foods can be incorporated into both healthy and unhealthy plant-based diet indices associated with coronary heart disease

Abstract Background One approach to test for differential associations between plant foods with health uses a scoring approach: foods categorized into animal or ‘healthy’ plant-based or ‘unhealthy’ plant-based groups to construct a plant-based diet index (PDI), healthy PDI (hPDI), and unhealthy PDI ...
Yasaman Jamshidi-Naeini, Beate Henschel, James M. Shikany, David B. Allison, Andrew W. Brown   +4 more
openaire   +2 more sources

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source