Results 141 to 150 of about 25,012,692 (251)

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

The Association Between Plant-Based Diet and Gallstone Disease: A Case-Control Study

BACKGROUND: Recent studies have emphasized the role of plant-based diets in reducing the risk of gallstone disease (GD) by reducing oxidative stress and inflammation. This study aimed to investigate the association between plant-based diet indices and GD
Sadeghi, Amir, Kheirizadeh, Ava, Ghorbani, Moloud, Yari, Zahra, Hekmatdoost, Azita, Ebrahimizadeh, Mohammad Hossein   +5 more
core   +1 more source

Does partial replacement of animal protein with plant protein in the diet affect components of metabolic syndrome, adropin levels, and the atherogenic index of plasma? Results from a parallel randomized clinical trial in adults with metabolic syndrome

Nutrition & Diabetes
Background Few studies evaluated the effect of different proportions of dietary plant- and animal-based protein on metabolic syndrome (MetS) and its related biomarkers.
Farnaz Shahdadian, Mahsa Rezazadegan, Parisa Rouhani, Awat Feizi, Gholamreza Askari, Zahra Moradmand, Parvane Saneei, Sayyed Morteza Safavi   +7 more
doaj   +1 more source

Plant-based dietary index and body weight in people with type 1 diabetes: a secondary analysis of a randomized clinical trial

Frontiers in Nutrition
ObjectiveThis secondary analysis tested the relationship of a plant-based diet index (PDI), healthful PDI (hPDI), and unhealthful PDI (uPDI), with weight loss in adults with type 1 diabetes.MethodsFifty-eight adults with type 1 diabetes were randomized ...
Hana Kahleova, Ilana Fischer, Reagan Smith, Joseph Himmelfarb, Tatiana Znayenko-Miller, Richard Holubkov, Neal D. Barnard, Neal D. Barnard   +7 more
doaj   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Nutritional Adequacy of the Mediterranean Diet

, 2015
The Mediterranean dietary pattern (MDP) encapsulates a beneficial fatty acid profile with high monounsaturated fatty acids content, a low proportion of carbohydrate, and high intake of dietary fiber and antioxidant compounds that work together to produce
Román-Viñas, Blanca, Itandehui Castro-Quezada, Blanca Román-Viñas, Lluís Serra-Majem, Castro-Quezada, Itandehui, Serra-Majem, Lluís   +5 more
core   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source