Results 191 to 200 of about 7,630,762 (341)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Future perspectives in mass spectrometry of plant lipids. [PDF]
Gutbrod K, Dörmann P.
europepmc +1 more source
Seventh workshop on seedling physiology and growth problems in oak plantings (abstracts); 1998 September 27-29; South Lake Tahoe, CA. [PDF]
Douglas D. McCreary, J. G. Isebrands
openalex +1 more source
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A field experiment was carried out at the Agricultural Research Station in Wasit Governorate, with a design of RCBD this study aimed to determine the role of Bacillus, Azotobacter, and organic fertilizers on soil biological and chemical properties and ...
Haider A. Al-Maamori
doaj
Artificial soil (ArtSoil): Recreating soil conditions in synthetic plant growth media. [PDF]
Kaplunova V +8 more
europepmc +1 more source

