Results 111 to 120 of about 292,817 (303)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Verification at the protein level of the PIF4-mediated external coincidence model for the temperature-adaptive photoperiodic control of plant growth in Arabidopsis thaliana.

, 2013
Plant circadian clock controls a wide variety of physiological and developmental events, which include the short-days (SDs)-specific promotion of the elongation of hypocotyls during de-etiolation and also the elongation of petioles during vegetative ...
Mizuno, T., Nakamichi, N., Nomoto, Y., Miyachi, M., Yamashino, T., Lorrain, S., Ito, S., Fankhauser, C.   +7 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Metabolomic Study of Sorghum (Sorghum bicolor) to Interpret Plant Behavior under Variable Field Conditions in View of Smart Agriculture Applications. [PDF]

J Agric Food Chem, 2021
Mandrone M, Chiocchio I, Barbanti L, Tomasi P, Tacchini M, Poli F.   +5 more
europepmc   +1 more source

Seed sowing shifts native–exotic richness relationships in favor of natives during restoration

Ecosphere
A central goal of ecological restoration is to promote diverse ecosystems dominated by native species, but restorations are often plagued by exotic species.
Tyler J. Bassett, Emily Grman, Lars A. Brudvig   +2 more
doaj   +1 more source

The transcriptome of Nacobbus aberrans reveals insights into the evolution of sedentary endoparasitism in plant-parasitic nematodes

, 2014
This work was supported by the Biotechnology and Biological Sciences Research Council and The James Hutton Institute (JHI). The James Hutton Institute receives funding from the Scottish Government.
Jones, John T., Cock, Peter J. A., Urwin, P.E., Eves-van den Akker, Sebastian, Cock, P.J.A., Danchin, Etienne, Danchin, Etienne G. J., Lilley, Catherine J., Urwin, Peter E., Jones, J.T., Lilley, C.J., Eves-van den Akker, S, Rancurel, Corinne   +12 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Plant encoded 1-aminocyclopropane-1-carboxylic acid deaminase activity implicated in different aspects of plant development

, 2009
Proper plant development is dependent on the coordination and tight control of a wide variety of different signals. In the study of the plant hormone ethylene, control of the immediate biosynthetic precursor 1-aminocyclopropane-1-carboxylic acid (ACC) is
McDonnell, Lisa, Plett, Jonathan M. (R17232), Regan, Sharon   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Salvia officinalis induces antidepressant-like effect, anxiolytic activity and learning improvement in hippocampal lesioned and intact adult rats.

Bangladesh Journal of Pharmacology, 2018
The anxiolytic and antidepressant like effects of Salvia officinalis extract (50, 100 and 200 mg/kg) were evaluated using marble burying, forced swimming and open-field tests in intact and hippocampal lesioned rats. Additionally, S.
Zineb El Gabbas, Kenza Bezza, Jawad Laadraoui, Rachida Makbal, Rachida Aboufatima, abderrahman Chait   +5 more
doaj   +1 more source