Results 91 to 100 of about 644,214 (270)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Plant genetic resources for agriculture, plant breeding, and biotechnology: Experiences from Cameroon, Kenya, the Philippines, and Venezuela [PDF]
"Local farming communities throughout the world face binding productivity constraints, diverse nutritional needs, environmental concerns, and significant economic and financial pressures.
Borges, Orangel +7 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Microalgae production for commercial purposes in the Azores [PDF]
, 2011 IBBA Strategic Planning - Workshop III, Plant Biotechnology Ponta Delgada, 25 Janeiro ...
Mota, Gonçalo +3 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
An Analysis of McLean County, Illinois Farmers' Perceptions of Genetically Modified Crops [PDF]
McLean County, Illinois farmers were surveyed in order to explore and analyze their perceptions of genetically modified crops and their genetically modified cropping decisions.
Chimmiri, Nagesh +2 more
core +1 more source
Contributions of biotechnology to meeting future food and environmental security needs [PDF]
, 2018 Biotechnology, including genetic modifications, can play a vital role in helping to meet future food and environmental security needs for our growing population.
Gartland, Jill S., Gartland, Kevan
core +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Analysis of agricultural biotechnolgy firms in the United States with regard to product development and financial resources [PDF]
, 2000 Agricultural biotechnology is a growing industry that creates many benefits. Through plant and animal science, this industry improves efficiency and reduces costs for agriculture by researching genetics of plants and animals and creating changes in the ...
Nickles, Lori
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