Results 51 to 60 of about 22,852 (201)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Plant Biotechnology: Applications in In Vitro Plant Conservation and Micropropagation

Horticulturae
Micropropagation and conservation using in vitro methods are one of the most important technologies used to maintain the gene pool and genetic diversity [...]
Rupesh Kumar Singh, Vasiliy A. Chokheli
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Evaluation of the knowledge of a population about the risk of plantain and banana transformed with Black Sigatoka resistant genes

Biotecnología Vegetal, 2007
An increasing impact of plant biotechnology on society is present in all over the world. Scientific understanding should be developed on people so they can be able to make right personal decisions and participate in public debate about this technology ...
José M. Machado-Rodríguez
doaj  

Applications of Plant Biotechnology: In Vitro Propagation and Plant Transformations

Plants
Modern plant biology stands at a transformative juncture where integrating advanced tissue culture, high-throughput genomics, and precise genome editing is driving a new era of agricultural resilience [...]
Humberto Prieto
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Plant biotechnology helps sustainable vegetable breeding

Discover Plants
The rapid surge in global population, increasing demand for high-quality nutritious food, and climate crisis have posed a significant threat to sustainable vegetable production systems.
Srija Priyadarsini, Saurabh Singh, Alok Nandi, Ferdinando Branca   +3 more
doaj   +1 more source

Aptamers as emerging tools for plant disease management: From biosensing to active modulation

iScience
Summary: Conventional methods for plant disease detection and management often face limitations in sensitivity, specificity, and field applicability. Aptamers, with high affinity and specificity, present a promising alternative.
Fuguo Liu, Yu Zhang, Zhixuan Wei, Hongsen Wu, Yanhui Jia, Xiaofang Li   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source