Results 41 to 50 of about 1,261,885 (193)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Quantitative predictions on auxin-induced polar distribution of PIN proteins during vein formation in leaves [PDF]

, 2010
The dynamic patterning of the plant hormone auxin and its efflux facilitator the PIN protein are the key regulator for the spatial and temporal organization of plant development.
A. Delbarre, A. Marchant, A. Newell, A.G. Rolland-Lagan, A.S. Usenko, C.L. Howe, C.L. Wenzel, D. Koenig, D. Reinhardt, E. Benková, E. Frey, E. Scarpella, E. Wangermann, E.M. Bayer, E.M. Kramer, E.M. Kramer, F. Feugier, F. Rapparini, F.A.F.C. Went, F.G. Feugier, G.J. Mitchison, G.J. Mitchison, G.J. Mitchison, H. Jönsson, J. Friml, J. Friml, J. Petrasek, J. Petrášek, J.A. Raven, K. Alim, K. Ljung, K. Okada, L. Gälweiler, L.E. Sieburth, M. Ibañes, M. Sauer, M.G. Sawchuk, M.H.M. Goldsmith, O. Hamant, P. Dhonukshe, P. Ortoleva, P. Sahlin, P.A. Lawrence, P.H. Rubery, R. Benjamins, R. Swarup, R.G. Casten, R.M.H. Merks, R.S. Smith, R.S. Smith, S. Pollmann, S. Stoma, T. Berleth, T. Paciorek, T. Sachs   +54 more
core   +3 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Functional analysis of plant Mei2-like proteins : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand [PDF]

, 2003
Molecular techniques were used to analyse the function of a novel class of RNA-bindmg proteins in plants, termed Mei2-like. The biochemical function of this class of proteins is unclear Although the conserved presence of three RNA recognition motifs ...
Leung, Susanna Chui-Shan
core  

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Design approach for photovoltaic power stations for demand-side requirements and competitive energy cost [PDF]

, 2008
[Abstract]: Photovoltaic (PV) plants can be constructed of different sizes capable of delivering the same rated power, however for different operation times. A scoping-factor is being introduced reflecting the peak power the plant is able to supply.
Kamel, Fouad
core  

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Bioactive Compounds From Torbangun [Plectranthus Amboinicus (Lour.) Spreng] Chloroform Fraction Induce Apoptosis in Breast Cancer (Mcf-7 Cells) in Vitro [PDF]

, 2017
Torbangun (Plectranthus amboinicus (Lour.) Spreng) is a medicinal plant that has been traditionally used in tropical countries to cure various illnesses.
Andarwulan, N. (Nuri), Giriwono, P. E. (Puspo), Pamungkas, J. (Joko), Yulianto, W. (Wahid)   +3 more
core  

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source