Results 51 to 60 of about 150,449 (263)

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Linking Leaf Economic Traits With Forage Quality Across Temperate Grasslands Under Ambient and Drought Conditions

Ecology and Evolution
Increases in droughts may disrupt the life‐supporting services of grasslands, including the forage provision for herbivores. However, less is known about drought impacts on forage quality (i.e., dynamics of the cell characteristics of leaves and stems of
Taofeek O. Muraina, Amarante Vitra, Massimiliano Probo, Jason P. Martina, Alexandre Buttler, Pierre Mariotte   +5 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

The High-Altitude Volcanic Caves of Mount Etna (Eastern Sicily): A Relevant Refuge for Some Ptero-Bryophyte Communities

Land
A phytosociological analysis of the plant communities in high-altitude volcanic caves of Mount Etna (Sicily), based on literature data and unpublished relevés, is presented.
Marta Puglisi, Giulia Bacilliere, Giulia Miraglia, Dario Teri, Saverio Sciandrello   +4 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Editorial: Women in chemical ecology 2022

Frontiers in Ecology and Evolution, 2023
Maria L. Pappas, Dani Lucas-Barbosa, Dani Lucas-Barbosa, Anne-Marie Cortesero   +3 more
doaj   +1 more source

Indicative properties on snow cover based on the results of experimental studies in the winter 2011/12 in the central part of the East European Plain

Лëд и снег, 2015
Local and regional differences in the snow formation were studied in different landscapes of the central part of the East European Plain – within reserves in the Moscow and Tver’ regions (south-north direction); the study period is the winter 2011/12 ...
L. M. Kitaev, R. A. Chernov, V. A. Ableeva, E. D. Korobov   +3 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source