Results 41 to 50 of about 430,342 (315)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Enhanced production of lupeol through elicitation in in vitro shoot cultures of snake grass (Clinacanthus nutans)

Notulae Scientia Biologicae, 2022
Clinacanthus nutans (Acanthaceae), generally known as ‘snake grass’, has diverse uses in customary system of herbal medicine. The species is endowed with various bioactive compounds exhibiting extensive pharmacological properties.
Somarajan L. CHIPPY, Vijayakumar T. ANJU VIJAY, Achuthan S. HEMANTHAKUMAR, Padmesh P. PILLAI, Thankappan S. PREETHA   +4 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

A robust in-vitro protocol for shoot multiplication of Echinacea angustifolia

Current Plant Biology, 2021
Echinacea angustifolia is an important medicinal and ornamental plant found in various regions of the world. This species may become threatened due to over-exploitation for medicinal uses.
Sumira Tyub, Ph.D, Shabeer Ahmad Dar, Ishfaq Maqbool Lone, Aabid Hussain Mir, Ph.D, Azra N. Kamili   +4 more
doaj  

Cultural diversity and plant-level productivity [PDF]

Regional Science and Urban Economics, 2012
Abstract Using comprehensive data for German establishments, we estimate plant-level production functions to analyze if “cultural diversity” affects total factor productivity. We distinguish diversity in the establishment's workforce (the micro level) and in the aggregate labor force of the region where the plant is located (the macro level). We find
Trax, Michaela, Brunow, Stephan, Suedekum, Jens   +2 more
openaire   +8 more sources

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Anatomy, Flow Cytometry, and X-Ray Tomography Reveal Tissue Organization and Ploidy Distribution in Long-Term In Vitro Cultures of Melocactus Species

Frontiers in Plant Science, 2020
Cacti have a highly specialized stem that enables survival during extended dry periods. Despite the ornamental value of cacti and the fact that stems represent the main source of explants in tissue culture, there are no studies on their morpho-anatomical
Gabriela Torres-Silva, Elyabe Monteiro Matos, Ludmila Freitas Correia, Evandro Alexandre Fortini, Wellington Santos Soares, Diego Silva Batista, Caio Gomide Otoni, Aristéa Alves Azevedo, Lyderson Facio Viccini, Andréa Dias Koehler, Sheila Vitória Resende, Chelsea Dvorak Specht, Wagner Campos Otoni   +12 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

The homogenization of China's city flowers and city trees

People and Nature
Cultural homogeneity, similar to the loss biodiversity, is a significant global issue that is increasingly gaining attention. City flowers and city trees (CFTs) serve as emblematic cultural symbols of modern cities, often referred to as the ‘green ...
Zhuo Cheng, Ziyi Wu, Weizhe Chen, Wenxuan Li, Chen Lin, Qing Zhang, Chunlin Long   +6 more
doaj   +1 more source