Results 171 to 180 of about 1,325,312 (300)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Optimizing Plant Density and Row Spacing Enhances Growth, Yield and Quality of Waxy Maize on the Loess Plateau. [PDF]

Plants (Basel)
Xie L, Su BJ, Zhang YN, Zhang DS, Han JJ, Li HM, Feng WJ, Du TQ, Cui FZ, Xue JF.   +9 more
europepmc   +1 more source

Physiological responses, yield and medicinal substance (andrographolide, AP1) accumulation of Andrographis paniculata (Burm. f) in response to plant density under controlled environmental conditions. [PDF]

PLoS One, 2022
Chutimanukul P, Mosaleeyanon K, Janta S, Toojinda T, Darwell CT, Wanichananan P.   +5 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Determining optimum plant density and nitrogen rate using field experiment and model simulation. [PDF]

Sci Rep
Desta BT, Tesema SE, Mekuria GF, Gezahegn AM, Lemma AZ.   +4 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

A Bayesian framework to model variance of grain yield response to plant density. [PDF]

Plant Methods
Giordano N, Hayes D, Hefley TJ, Lacasa J, Beres BL, Haag LA, Lollato RP.   +6 more
europepmc   +1 more source

Selfing rates vary with floral display, pollinator visitation and plant density in natural populations of Mimulus ringens. [PDF]

J Evol Biol, 2021
Christopher DA, Karron JD, Semski WR, Smallwood PA, Trapnell DW, Mitchell RJ.   +5 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A probabilistic sampling strategy for estimating plant density in Posidonia oceanica meadows. [PDF]

Environ Monit Assess
Bartolini A, Marcelli A, Di Biase RM, Fattorini L, Ferrini S.   +4 more
europepmc   +1 more source