Results 171 to 180 of about 5,197,418 (291)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Bayesian framework to model variance of grain yield response to plant density. [PDF]

Plant Methods
Giordano N, Hayes D, Hefley TJ, Lacasa J, Beres BL, Haag LA, Lollato RP.   +6 more
europepmc   +1 more source

Selfing rates vary with floral display, pollinator visitation and plant density in natural populations of Mimulus ringens. [PDF]

J Evol Biol, 2021
Christopher DA, Karron JD, Semski WR, Smallwood PA, Trapnell DW, Mitchell RJ.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A probabilistic sampling strategy for estimating plant density in Posidonia oceanica meadows. [PDF]

Environ Monit Assess
Bartolini A, Marcelli A, Di Biase RM, Fattorini L, Ferrini S.   +4 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Optimizing Maize Yield With Hybrids Tolerant of High Plant Density in West and Central Africa. [PDF]

Plant Environ Interact
Ygzaw W, Ifie BE, Ribeiro PF, Adu GB, Danquah EY, Offei SK, Tongoona PB.   +6 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Modeling Growth Dynamics of <i>Lemna minor</i>: Process Optimization Considering the Influence of Plant Density and Light Intensity. [PDF]

Plants (Basel)
von Salzen J, Petersen F, Ulbrich A, Streif S.   +3 more
europepmc   +1 more source

Optimized nitrogen rate, plant density, and irrigation level reduced ammonia emission and nitrate leaching on maize farmland in the oasis area of China. [PDF]

PeerJ, 2022
Asibi AE, Yin W, Hu F, Fan Z, Gou Z, Yang H, Guo Y, Chai Q.   +7 more
europepmc   +1 more source