Results 31 to 40 of about 452,746 (268)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The LHT Gene Family in Rice: Molecular Characterization, Transport Functions and Expression Analysis

Plants, 2023
Amino acid transporters (AATs) are integral membrane proteins and play important roles in plant growth and development as well as environmental responses.
Tian Fan, Chunting Wu, Weiqi Yang, Tianxiao Lv, Yuping Zhou, Changen Tian   +5 more
doaj   +1 more source

Design of the MIDES plant [PDF]

, 2021
Abstract This chapter presents the full design of two microbial desalination cells (MDCs) at pilot-plant scale from the MIDES project. The final MDC pilot unit design was based on the knowledge gained through up scaling of the MDC from lab- to prepilot scale.
Juan Arévalo, Patricia Zamora, Vicente F. Mena, Naiara Hernández-Ibáñez, Victor Monsalvo-Garcia, Frank Rogalla   +5 more
openaire   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Pre-design of a Mini CSP Plant

Energy Procedia, 2015
AbstractThe REELCOOP project funded by the European Union aims at developing and demonstrating three small scale solar electricity generating units with two of them using thermal power cycles and one using PV. The system described here includes parabolic trough collectors and an organic Rankine cycle (ORC), enhanced by a biogas boiler and a thermal ...
Krüger, Dirk Rinus, Khenissi, Abdallah, Dieckmann, Simon, Bouden, Chiheb, Baba, Abdallah, Oliveira, Armando, Soares, Joao, Rojas Bravo, Esther, Ben Cheikh, Ridha, Orioli, Francesco, Gasperini, Daniel, Hennecke, Klaus, Schenk, Heiko   +12 more
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

CPK1 activates CNGCs through phosphorylation for Ca2+ signaling to promote root hair growth in Arabidopsis

Nature Communications
Cyclic nucleotide-gated channel 5 (CNGC5), CNGC6, and CNGC9 (CNGC5/6/9 for simplicity) control Arabidopsis root hair (RH) growth by mediating the influx of external Ca2+ to establish and maintain a sharp cytosolic Ca2+ gradient at RH tips.
Meijun Zhu, Bo-Ya Du, Yan-Qiu Tan, Yang Yang, Yang Zhang, Yong-Fei Wang   +5 more
doaj   +1 more source