Results 141 to 150 of about 635,909 (318)

Application of velocity-based gain-scheduling to lateral auto-pilot design for an agile missile

, 2001
In this paper a modern gain-scheduling methodology is proposed which exploits recently developed velocity-based techniques to resolve many of the deficiencies of classical gain-scheduling approaches (restriction to near equilibrium operation, to slow ...
Tsourdos, A., Leithead, W.E., White, B., Leith, D.J.   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Multivariable control of a flotation plant simulator

, 1989
Includes bibliography.This dissertation describes the application of two multivariable frequency domain techniques in order to design controllers for a “flotation plant”. A flotation plant simulator was designed and constructed at the University of Cape
Fisher, I P
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Inside out. Exploring invisible spaces of material flow through a critical design process [PDF]

, 2019
This thesis is a creative exploration of sustainability and design, investigating different aspects of materiality and how critical design could be used as a method for understanding the material flow and identifying value opportunities.
Corin, Anu
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Desat1-mediated lipid homeostasis mitigates 20E-induced lipotoxicity in blood-fed mosquitoes

Nature Communications
Adequate lipid storage capacity is crucial for animal reproductive success, especially in female mosquitoes, which must accumulate sufficient lipid reserves to support egg production.
Peilu Sun, Guandong Wang, Bingchen Yang, Yiguan Wang, Chunlai Cui, Ling Dong, Yifei Li, Tao Zhou, Fang Li, Sibao Wang   +9 more
doaj   +1 more source

The Plant Ontology as a Tool for Comparative Plant Anatomy and Genomic Analyses

The Plant Ontology (PO;http://www.plantontology.org/" is a publicly available, collaborative effort to develop and maintain a controlled, structured vocabulary ('ontology') of terms to describe plant anatomy, morphology and the stages of plant ...
Walls, Ramona L., Jaiswal, Pankaj, Stevenson, Dennis W., Elser, Justin, Arnaud, Elizabeth, Shrestha, Rosemary, Mungall, Christopher J., Lang, Daniel, Berardini, Tanya Z., Yamazaki, Yukiko, Preece, Justin, Huala, Eva, Menda, Naama, Smith, Barry, Schaeffer, Mary, Gandolfo, Maria A., Athreya, Balaji, Reski, Ralf, Li, Donghui, Cooper, Laurel, Rensing, Stefan, Hiss, Manuel   +21 more
core   +1 more source