Results 191 to 200 of about 473,806 (265)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Sclareol Production Driven by Advanced Synthetic Biology Strategies. [PDF]

ACS Omega
Yu Y, Wang L, Zhang Y, Zhang R, Shah AA, Gong C.   +5 more
europepmc   +1 more source

Design, implementation and validation of a web-based dynamic simulation platform for pumped storage hydropower plant control systems. [PDF]

PLoS One
Zhang C, Liang T, Li Y, Zhang W, Wang Y.
europepmc   +1 more source

Engineering principles in plant metabolism: integrating control, mechanics, and transport under dynamic environments. [PDF]

Plant Physiol
Nies T, Ebeling J, Matuszyńska A.
europepmc   +1 more source

Engineering rhizobacterial communities for soil and plant health. [PDF]

Microbiology (Reading)
Garcia-Perez E, Perrin L, Malone JG, Thompson CMA, Guiziou S.   +4 more
europepmc   +1 more source

Symbiotic interactions of plant microbiota in alleviating stress: a review. [PDF]

Front Plant Sci
Prasad SS, Singh A, Ramteke P, Veres C, Büchner R, Vágvölgyi C.   +5 more
europepmc   +1 more source